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However, current phenome-wide association studies rely on pre-defined, single-variable phenotypes or expert-crafted features, which limits their ability to capture clinically meaningful non-linear effects and cross-phenotype interactions. To address this, we propose CPAgents, an iterative phenotype-Composition framework for cardiovascular Phenome-wide association study (PheWAS) that automatically constructs and validates interpretable composite phenotypes (e.g., polynomial, ratio, and interaction forms) from base imaging features. Specifically, our system coordinates three agents: (i) an Analyst that identifies statistical pathologies and nominates candidate transformations; (ii) a Proposer that generates constrained, medically and statistically motivated e","title":"CPAgents: Agentic Composite Phenotype Generation for Cardiac Disease Association","url":"https://arxiv.org/abs/2606.28179","vendor":"arxiv_cs_ai"},"summary":"arXiv:2606.28179v1 Announce Type: cross \nAbstract: Identifying robust associations between cardiac imaging phenotypes and clinical diseases is fundamental to population-scale cardiovascular research and reliable risk stratification. However, current phenome-wide association studies rely on pre-defined, single-variable phenotypes or expert-crafted features, which limits their ability to capture clinically meaningful non-linear effects and cross-phenotype interactions. To address this, we propose CPAgents, an iterative phenotype-Composition framework for cardiovascular Phenome-wide association study (PheWAS) that automatically constructs and validates interpretable composite phenotypes (e.g., polynomial, ratio, and interaction forms) from base imaging features. Specifically, our system coordinates three agents: (i) an Analyst that identifies statistical pathologies and nominates candidate transformations; (ii) a Proposer that generates constrained, medically and statistically motivated e","title":"CPAgents: Agentic Composite Phenotype Generation for Cardiac Disease Association","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-06-29T04:44:03Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2606.28179"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:16c6d0dab99bd5d6061ba67e6a6634a570314dabd5b89e5fe65636ee2360f8c18553db224c7f5937a16b00eb796927a8f0ede5f353e03a861190c07c8647d208","signer":"crovia.substrate","subject":{"observed_at":"2026-06-29T04:44:03Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2606.28179"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"c1e1e8a819f03f4c208245ceb6c8f284f14a2ff38dc8900971114025bf9ca3f8","leaf_index":261431,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"d062d971f6f3d7929aac36aa58f0c952f3f1658e6f828ae0f9632622326edba4","side":"left"},{"sibling":"dfef6b40a5a9cc9df989e5c06ffa07d159a48349d24a421f3d68eb4b2e8da070","side":"left"},{"sibling":"be0b40c53956f3b3fa34b60c0625cea636d9239784a3f1b110aa1e2afbebaa12","side":"left"},{"sibling":"84c14f8e01284da67c9e5ab5aad1d4fed2482a09643bd1241f99d01a8d56166e","side":"right"},{"sibling":"2822a86953ba809f6211c399bc5537914e533fc8ed9db9d6a73638c2f06c5b41","side":"left"},{"sibling":"28f6d579aa317feaa020f8d687c6d588f190996b8a9f473dfbb0a5df14ba3293","side":"left"},{"sibling":"f598b90b37d7f9301fa045df6c69e9936b54d84361d68c339f86d13ecd08335e","side":"right"},{"sibling":"4b4bda5fa1fb23989b8f6f192c36dadc8266c378c69d42945af35c9d6ab81a10","side":"right"},{"sibling":"6d1df65d14253ed3a13c03e25aa9adcd9a091d8062a82e8586bcaee74013b90e","side":"left"},{"sibling":"9f9daa9d12e65b219f34c92aec45450536b79a42b8892050d66961432ae28ed1","side":"right"},{"sibling":"b5725d7b0807dc6da32d9788f20057fa8726be38d30a9ebdabc605ae92739122","side":"left"},{"sibling":"e321b2cac14cbe28f76ccb7938249a40ff60cd5d2128b5634be046ea10e984b8","side":"left"},{"sibling":"5900dc6c7d13855af9d0385baf1691ec386df33e450c422af1cabe0a36e40ad8","side":"left"},{"sibling":"ae636ddee98c71ab7a7dc55ddfab70c7f710a2b6abfdf7a8b5d16a4017d1c0d1","side":"left"},{"sibling":"f29798d8bb6aa9900eab878992d9ff0c53266debd87472f31ab26a6a3fb55880","side":"left"},{"sibling":"a04392fb9f2a3a620840e3b3fecd93d12e6d224e481c162389d8ae64e7194599","side":"left"},{"sibling":"c300cf0154c136afc09b1702a0be98f4ba5b6dc5cf57e8cc714ec1eaf4196eff","side":"left"},{"sibling":"d841ad93efda0869e5eb97678f348f03f5caab4353e05ff4bf18f47fb945b822","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":261662,"merkle_root":"aa8865c239aa2eb6c8aa7c6250f56b3cd5709854a8a07f6a29eb4ddd8802cb6f","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260629T053701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-06-29T05:38:02Z","sig_algorithm":"ed25519","signature":"476329233e82fb35fba2552ddc5d1d75b2bdd8513bbd281e9c40a0b8e475df374a62dcd8b456b0c5e8815984f5b4bf0983ae95d2cf4d7412ebb13a433b933c0a","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_11be7bcd99be013d1fb668c7211c79f0b5559eebdf0c13f686056cf4e42e29cf"}}