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Prognostic modeling in HCC is informed by rich multimodal information from multiparametric MRI and radiology reports from routine clinical practice. Existing prognostic vision-language models (VLMs) learn a single entangled latent representation that blends hepatic and tumor-related factors, limiting both accuracy and biological interpretability. We present BioFact-MoE, a biologically factorized Mixture of Experts (MoE) framework that explicitly decomposes liver and tumor factors via biologically supervised experts within a residual MoE survival architecture. On a HCC cohort of N=588 patients (pretrained on 4,582 3D MRI image-report pairs), BioFact-MoE consistently improves surviva","title":"BioFact-MoE: Biologically Factorized Mixture of Experts for Vision-Language Prognostic Modeling in Hepatocellular Carcinoma","url":"https://arxiv.org/abs/2605.26376","vendor":"arxiv_cs_ai"},"summary":"arXiv:2605.26376v1 Announce Type: cross \nAbstract: Hepatocellular carcinoma (HCC) is biologically heterogeneous, shaped by the interplay between hepatic functional reserve and tumor-related oncologic factors; thus, similar survival outcomes may reflect fundamentally different underlying biological processes. Prognostic modeling in HCC is informed by rich multimodal information from multiparametric MRI and radiology reports from routine clinical practice. Existing prognostic vision-language models (VLMs) learn a single entangled latent representation that blends hepatic and tumor-related factors, limiting both accuracy and biological interpretability. We present BioFact-MoE, a biologically factorized Mixture of Experts (MoE) framework that explicitly decomposes liver and tumor factors via biologically supervised experts within a residual MoE survival architecture. On a HCC cohort of N=588 patients (pretrained on 4,582 3D MRI image-report pairs), BioFact-MoE consistently improves surviva","title":"BioFact-MoE: Biologically Factorized Mixture of Experts for Vision-Language Prognostic Modeling in Hepatocellular Carcinoma","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-05-27T04:43:18Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2605.26376"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:b116f047f6c97c22dd1a116991eb07ebc6c529e47b3628f7f3f4af423e70c9c629b43ce979c0f12b7e3e47b3a7c28edf48cbd0ba322829ab25c7409a794c180e","signer":"crovia.substrate","subject":{"observed_at":"2026-05-27T04:43:18Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2605.26376"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"4ba8d07a7dad0fc2aee822c078955eba168169d270757cd92f1779496c76478a","leaf_index":153670,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"c3fd0e7c57e7f827383c2f4978e87802728c05ad24aa30fd6211c3ef0b142a25","side":"right"},{"sibling":"59cce80e694026bdaebf2fed5aef87caeed6fba3d5b0e667b5d2701099bb2de4","side":"left"},{"sibling":"a5a91691597a662a7e8023a70b9414ed9e1afd20fbed2f202627a3f7e4f87d53","side":"left"},{"sibling":"f58f423bc857db9d9b04d24e97bf9122e19f04f3cb3e16d721d0c35cc4ba6855","side":"right"},{"sibling":"76d7e9aab53a022b48740c7341ac525aa9f0633225ab5460d284eddb7780240f","side":"right"},{"sibling":"6c9ab638d911822a9031db3f48c0a1ef373237cc0d10ec931e6c9c74b4922252","side":"right"},{"sibling":"727ac1dfc33933f05b7eed6f887414eb57d6283ba0cbf0d562eadb6f86c3d644","side":"left"},{"sibling":"e6fcc8fd02ff764f6e74465d070f84e313e858647d901e3ee00b83931106f26c","side":"right"},{"sibling":"c56e46802f42ead6bcf79619c80428b6dc22e9afc9611a87f0d04a5ef9acadd7","side":"right"},{"sibling":"3165125427a29042fc9d02858a59a68858dbdcb2e19d1afa5f6dd6a95cfbce6a","side":"right"},{"sibling":"04b9a68b8ec6fa37251564383c685c23ce69e5e031df4eae69f79a3a334b68bf","side":"right"},{"sibling":"816f233274bb10f5a122aac086a0c8c697b78fec67a4af55190bb596b7506fab","side":"left"},{"sibling":"d415e6939aee710631f5062799379b547d2c3e3d9a68f263bbb5a693285ab2ca","side":"left"},{"sibling":"374c02d15fb12bd356c179c94766043a982052c6132af8bfc15361b431ffa9f7","side":"right"},{"sibling":"35ca36cee447f0ef7064a25d55f59357c66901e31427729c4c1d8b14aa8adb6c","side":"left"},{"sibling":"990705096edf483cc877217308f731dc42d6f6d99f82880167bbdbbfef32560a","side":"right"},{"sibling":"dd265753d95fa2e2fb4f5768e37fab6f691ccff09ad60d0910ff7dc23bac9226","side":"right"},{"sibling":"d841ad93efda0869e5eb97678f348f03f5caab4353e05ff4bf18f47fb945b822","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":154065,"merkle_root":"4993cfdc172e7880b60667f16789dc2e831ff000f81bb1ecba248e73f1510eca","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260527T053701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-05-27T05:37:36Z","sig_algorithm":"ed25519","signature":"76ecf118011540405e96506e6219752df04a2850632f2903dc6f10e08b98bc5a42c8d9e1cb5b7c5bf714479806a403df5f34399afa40c23fbb71493a1f77bd0c","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_32b82b9e8affc0e51fdaf4032fafbaee3e1269fe8bda8cd2fe8d9128be15959e"}}