{"_canonicalization":{"envelope_id":"axm_ + sha256(envelope minus {signature, axiom_id, anchors})","envelope_signature":"ed25519(envelope minus {signature, axiom_id})","json":"sort_keys=True, separators=(',',':'), ensure_ascii=False, allow_nan=False, utf-8","leaf_hash":"sha256(0x00 || canonical_json(envelope_full))","seal_signature":"ed25519(seal minus {signature, sig_algorithm})"},"axiom_id":"axm_35aa0652f3bee474c7598cb298b61dd5f961ff733d0bb7862578050978d5f6fe","bitcoin_anchor":{"bitcoin_attestations":[],"calendar_attestations":[],"ots_url":"","stamped_at":"","status":"pending_next_stamp"},"envelope":{"anchors":[{"chain":"crovia.axiom_graph","height":0,"merkle_proof":"spider_vendor_press_v1","root_at_anchor":"spider_vendor_press_v1"}],"axiom_id":"axm_35aa0652f3bee474c7598cb298b61dd5f961ff733d0bb7862578050978d5f6fe","axiom_type":"AX.OBS","body":{"axiom_subtype":"news.vendor_press.v1","category":"news","fingerprint":"83a675fd0a6f170533d598087eeb7628a0ea018eb3e3dde61741f0b562307fbf","published":"Wed, 27 May 2026 00:00:00 -0400","receipt_hash":"83a675fd0a6f170533d598087eeb7628a0ea018eb3e3dde61741f0b562307fbf","schema":"spider.news.vendor_press.v1","spider":"vendor_press","spider_record":{"axiom_subtype":"news.vendor_press.v1","category":"news","decision_hint":"POSITIVE","envelope_target":"AX.OBS","fingerprint":"83a675fd0a6f170533d598087eeb7628a0ea018eb3e3dde61741f0b562307fbf","observed_at":"2026-05-27T04:43:18.926230Z","parent_run_hash":"6f581915edab4326e2b95fed7c82c2ee149e978d6d7c2443439442a927c31dfa","published":"Wed, 27 May 2026 00:00:00 -0400","runtime_version":"0.1.0","schema":"spider.news.vendor_press.v1","source_status":200,"source_url":"https://export.arxiv.org/rss/cs.AI","spider":"vendor_press","summary_excerpt":"arXiv:2605.26192v1 Announce Type: cross \nAbstract: Protein structure generative models excel at predicting single protein static structures from sequence, but routinely fail to capture the correct conformational state of protein complexes, critical for protein design and induced proximity modalities such as antibodies and PROTACs. While structural proteomics techniques like Cross-Linking Mass Spectrometry (XL-MS) and Hydrogen-Deuterium Exchange (HDX-MS) offer valuable spatial and dynamic insights, integrating these sparse, heterogeneous measurements into these models remains an open challenge. Here, we bridge this gap by combining structural proteomics data with the rich biophysical priors learned by pretrained diffusion models. We introduce AIMS-Fold, an inference-time guided-diffusion framework that actively steers the generative sampling trajectory using differentiable physical potentials derived from XL-MS spatial restraints and HDX-MS solvent accessibility profiles. We demonstrate","title":"Co-folding model guided by structural proteomics","url":"https://arxiv.org/abs/2605.26192","vendor":"arxiv_cs_ai"},"summary":"arXiv:2605.26192v1 Announce Type: cross \nAbstract: Protein structure generative models excel at predicting single protein static structures from sequence, but routinely fail to capture the correct conformational state of protein complexes, critical for protein design and induced proximity modalities such as antibodies and PROTACs. While structural proteomics techniques like Cross-Linking Mass Spectrometry (XL-MS) and Hydrogen-Deuterium Exchange (HDX-MS) offer valuable spatial and dynamic insights, integrating these sparse, heterogeneous measurements into these models remains an open challenge. Here, we bridge this gap by combining structural proteomics data with the rich biophysical priors learned by pretrained diffusion models. We introduce AIMS-Fold, an inference-time guided-diffusion framework that actively steers the generative sampling trajectory using differentiable physical potentials derived from XL-MS spatial restraints and HDX-MS solvent accessibility profiles. We demonstrate","title":"Co-folding model guided by structural proteomics","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-05-27T04:43:18Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2605.26192"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:872cd3bd802f15d34c48fc0c748960c64f621efe9c3318e308849321b569a4354bac0d3f35eace86d308548997735d4d6700d4edbacca7223dfab84609744004","signer":"crovia.substrate","subject":{"observed_at":"2026-05-27T04:43:18Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2605.26192"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"0862a1d1220cfaeeb8a897b02f52701805eb89dea5e811d5c271f4e308f217e9","leaf_index":153650,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"116dfbe5faa96f0f0f946997fdc868ce431f7f5efca72cce400bdbaf5fc0d1c3","side":"right"},{"sibling":"c7ae8db5d7aac7e4ed8c3a85e046ca971852e2ceceab45d4269d98675bbe64a6","side":"left"},{"sibling":"c74f4815c795ad1a94d632b116d47de6f0b0b39b22cd9979a73332928a4ab519","side":"right"},{"sibling":"fab506784e53299e524037dc4a384ad0ea8eedfbd9fbd922af93e0e4f6f75065","side":"right"},{"sibling":"43da306d445b109a21457c2f146327b66865a7ee35bab0ff38bce7a1df965410","side":"left"},{"sibling":"99164640ca01b6e99a61eafa08e989a9c1354aed40726311d98ae399dce42875","side":"left"},{"sibling":"20fef87d78d7a367f04b7046503b17acf0a805917fa54a478472e2f7833e4d1b","side":"right"},{"sibling":"e6fcc8fd02ff764f6e74465d070f84e313e858647d901e3ee00b83931106f26c","side":"right"},{"sibling":"c56e46802f42ead6bcf79619c80428b6dc22e9afc9611a87f0d04a5ef9acadd7","side":"right"},{"sibling":"3165125427a29042fc9d02858a59a68858dbdcb2e19d1afa5f6dd6a95cfbce6a","side":"right"},{"sibling":"04b9a68b8ec6fa37251564383c685c23ce69e5e031df4eae69f79a3a334b68bf","side":"right"},{"sibling":"816f233274bb10f5a122aac086a0c8c697b78fec67a4af55190bb596b7506fab","side":"left"},{"sibling":"d415e6939aee710631f5062799379b547d2c3e3d9a68f263bbb5a693285ab2ca","side":"left"},{"sibling":"374c02d15fb12bd356c179c94766043a982052c6132af8bfc15361b431ffa9f7","side":"right"},{"sibling":"35ca36cee447f0ef7064a25d55f59357c66901e31427729c4c1d8b14aa8adb6c","side":"left"},{"sibling":"990705096edf483cc877217308f731dc42d6f6d99f82880167bbdbbfef32560a","side":"right"},{"sibling":"dd265753d95fa2e2fb4f5768e37fab6f691ccff09ad60d0910ff7dc23bac9226","side":"right"},{"sibling":"d841ad93efda0869e5eb97678f348f03f5caab4353e05ff4bf18f47fb945b822","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":154065,"merkle_root":"4993cfdc172e7880b60667f16789dc2e831ff000f81bb1ecba248e73f1510eca","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260527T053701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-05-27T05:37:36Z","sig_algorithm":"ed25519","signature":"76ecf118011540405e96506e6219752df04a2850632f2903dc6f10e08b98bc5a42c8d9e1cb5b7c5bf714479806a403df5f34399afa40c23fbb71493a1f77bd0c","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_35aa0652f3bee474c7598cb298b61dd5f961ff733d0bb7862578050978d5f6fe"}}