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However, existing methods either adopt a one-pass strategy that implicitly assumes all layouts are equally important, or focus excessively on small regions at the cost of losing critical layout information. To address these limitations, we introduce Doc-CoB (Chain-of-Boxes), a simple-yet-effective framework that integrates coarse-to-fine layout-aware visual reasoning into multimodal large language models. Instead of directly zooming into small regions, Doc-CoB progressively focuses on query-relevant layouts while preserving global document information. Specifically, it first selects key layout boxes and then focuses on them for further understanding with visual prompting. 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