{"_canonicalization":{"envelope_id":"axm_ + sha256(envelope minus {signature, axiom_id, anchors})","envelope_signature":"ed25519(envelope minus {signature, axiom_id})","json":"sort_keys=True, separators=(',',':'), ensure_ascii=False, allow_nan=False, utf-8","leaf_hash":"sha256(0x00 || canonical_json(envelope_full))","seal_signature":"ed25519(seal minus {signature, sig_algorithm})"},"axiom_id":"axm_4206d79c2860bb7833d412e83ac1a53d4be36f87eae249c3d2214c5d946bf678","bitcoin_anchor":{"bitcoin_attestations":[],"calendar_attestations":[],"ots_url":"","stamped_at":"","status":"pending_next_stamp"},"envelope":{"anchors":[{"chain":"crovia.axiom_graph","height":0,"merkle_proof":"spider_vendor_press_v1","root_at_anchor":"spider_vendor_press_v1"}],"axiom_id":"axm_4206d79c2860bb7833d412e83ac1a53d4be36f87eae249c3d2214c5d946bf678","axiom_type":"AX.OBS","body":{"axiom_subtype":"news.vendor_press.v1","category":"news","fingerprint":"240b8d58b5e09a4926fe10e199e5f77d1d4958f31484d2a52aeb84ec80460aa6","published":"Thu, 02 Jul 2026 00:00:00 -0400","receipt_hash":"240b8d58b5e09a4926fe10e199e5f77d1d4958f31484d2a52aeb84ec80460aa6","schema":"spider.news.vendor_press.v1","spider":"vendor_press","spider_record":{"axiom_subtype":"news.vendor_press.v1","category":"news","decision_hint":"POSITIVE","envelope_target":"AX.OBS","fingerprint":"240b8d58b5e09a4926fe10e199e5f77d1d4958f31484d2a52aeb84ec80460aa6","observed_at":"2026-07-02T04:43:28.872255Z","parent_run_hash":"9f528c2a80e5b201c2a66ae885c05dd596ad2c3532bb4c6809c7c9704d10e650","published":"Thu, 02 Jul 2026 00:00:00 -0400","runtime_version":"0.1.0","schema":"spider.news.vendor_press.v1","source_status":200,"source_url":"https://export.arxiv.org/rss/cs.AI","spider":"vendor_press","summary_excerpt":"arXiv:2607.00733v1 Announce Type: cross \nAbstract: Mechanistic modeling via ordinary differential equations (ODEs) provides interpretable descriptions of complex dynamics and enables inference of underlying mechanisms, which is particularly valuable in clinical settings. However, in rare diseases, both the structure and parameters of the model are typically unknown, while individual-level data is scarce, noisy, heterogeneous, and subject to privacy constraints. In such settings, population-level summary statistics provide a practical privacy-preserving data representation, while capturing heterogeneity further requires modeling parameters as distributions rather than fixed values. Yet no existing method jointly discovers ODE structure and refines parameter distributions solely from summary statistics. We present AgentODE, an end-to-end framework that addresses this gap. An LLM proposes candidate ODE structures, while a tool-augmented inference agent iteratively refines parameter distri","title":"LLM-Guided ODE Discovery and Parameter Inference from Small-Cohort Aggregate Data","url":"https://arxiv.org/abs/2607.00733","vendor":"arxiv_cs_ai"},"summary":"arXiv:2607.00733v1 Announce Type: cross \nAbstract: Mechanistic modeling via ordinary differential equations (ODEs) provides interpretable descriptions of complex dynamics and enables inference of underlying mechanisms, which is particularly valuable in clinical settings. However, in rare diseases, both the structure and parameters of the model are typically unknown, while individual-level data is scarce, noisy, heterogeneous, and subject to privacy constraints. In such settings, population-level summary statistics provide a practical privacy-preserving data representation, while capturing heterogeneity further requires modeling parameters as distributions rather than fixed values. Yet no existing method jointly discovers ODE structure and refines parameter distributions solely from summary statistics. We present AgentODE, an end-to-end framework that addresses this gap. An LLM proposes candidate ODE structures, while a tool-augmented inference agent iteratively refines parameter distri","title":"LLM-Guided ODE Discovery and Parameter Inference from Small-Cohort Aggregate Data","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-07-02T04:43:28Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2607.00733"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:b3dff1e7393983c56aac63c77b2fccf21802fce17186bb2ff28d1f90b95e3a30b8d7571c090058c9c224e4c17f26470002c43a63be7628453750dca21f4d390a","signer":"crovia.substrate","subject":{"observed_at":"2026-07-02T04:43:28Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2607.00733"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"7f4766988b13bc7b04ef513c07d17750bfcf7345f0e551c3690198d213ea030b","leaf_index":272046,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"9379a119928c9e040e83164403f95f2e1e90c3cd4e0715d209f008961ae4060e","side":"right"},{"sibling":"827fddff39b48fac2312e7b65e3d00fb39ab99c089d249301fb31f1d1c23174f","side":"left"},{"sibling":"a6165c416783502652f5d302e52400c61e82a116e7edccc16d6fd4efd69ea5b1","side":"left"},{"sibling":"595928fd66c3be34ba0bbddaf8b749f57133f28c2d4e890c03b0f08c10908616","side":"left"},{"sibling":"5e112735a72be4737658d962a233033b927a9653768505bc20d163c4209edc8a","side":"right"},{"sibling":"4d2fc5371b5f72d00f2987c6fe788621caab768da28efd1e053e9f6b44aeb5eb","side":"left"},{"sibling":"fb20322888e405335fce4284c86a4bf0c12c4d6bc87c0453f3c09ad3354c7e5c","side":"right"},{"sibling":"940858731d5be758fd8a2eb1da57b23657abab31e76c3d2d4ca6f9ae60489517","side":"left"},{"sibling":"155ae596a5c6a5260be50ff412642fbd25f4587b43e04c56950c1dc544719be1","side":"right"},{"sibling":"4cfdd7f7072619c015edc477162c2cf29c6f70370acb8dbddf1eb590876d82fe","side":"left"},{"sibling":"43990c9db8fcb3172d821965dfac69152981af4108b8dc87bd32f15c0e56f4cf","side":"left"},{"sibling":"15dbacc2e5845fe3bb835797bb7647ab6f091e79adadd39f40c636980716c622","side":"right"},{"sibling":"7ecc1d0d471643b88d886db58cb02a77af4d1495674760c3867834550b143757","side":"right"},{"sibling":"8a09562f6b247c1c3cd1fea36cb3b8f1cf5c575479dd514573856a380a964bf5","side":"left"},{"sibling":"7b681d50e7d0a7b8d2a749507aed58030072539a90fab18de4f698743685cc00","side":"right"},{"sibling":"9b262645232510ff15bb7325ab858256f2914f711d2726caeafd49f5ca0fb7a9","side":"right"},{"sibling":"5bd94446b5721b713c5e4dcf4624b9bc682657ab2784af927caae7b80c297d7d","side":"right"},{"sibling":"21ac0b7091fe1133859bcd17b4f8da2fe37a2489d472dad508305740b483221b","side":"right"},{"sibling":"1cecb7f447febd025aac272837c80de218aecc6485d2395a509b2a1f1b9c746e","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":272319,"merkle_root":"dd4fa4deb1f207e8a7756821b4f940f39e9f06a25e6fa8500a21dd403318a5a7","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260702T053701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-07-02T05:38:06Z","sig_algorithm":"ed25519","signature":"68eb2e3bbc0f593bea7b5c3c110c90b6f4fe4fd8277d8dee7c866ba0471c1a50684aa4539c8a493e6d9c9202d8c03f4d897a0df3477e9ecd5b0ff03eb1016f00","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_4206d79c2860bb7833d412e83ac1a53d4be36f87eae249c3d2214c5d946bf678"}}