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In adaptive socio-technical systems this assumption may fail: regulatory change can alter incentives, agents can respond strategically, and the mapping from policy variables to aggregate outcomes can change. This paper studies such regime change as a transfer-learning problem in adaptive multi-agent systems. A policy regime is represented as a learning problem induced by an observable input distribution and a target function mapping policy variables to outcomes. We compare a blank-slate learner that searches a flexible hypothesis class in the new regime with a transfer learner whose effective hypothesis class is restricted by structural knowledge from the previous regime. 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We compare a blank-slate learner that searches a flexible hypothesis class in the new regime with a transfer learner whose effective hypothesis class is restricted by structural knowledge from the previous regime. 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