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These systems, however, remain fundamentally observational: they learn statistical associations from historical data and operate within previously observed biological and clinical states, limiting their ability to generalize to novel therapies or unobserved interventions.\n  We argue that AI in biomedicine is undergoing a structural transition. As biomedical decision-making increasingly depends on reasoning about intervention rather than extrapolation from past observations, predictive architectures become structurally insufficient. Systems that learn from historical data cannot, by construction, represent how biological systems evolve under perturbation, and therefore cannot reliably support decision-making in the presence of novel","title":"From Prediction to Intervention: The Evolution of AI in Biomedicine","url":"https://arxiv.org/abs/2605.16293","vendor":"arxiv_cs_ai"},"summary":"arXiv:2605.16293v2 Announce Type: replace-cross \nAbstract: Artificial intelligence has advanced rapidly in biomedicine through large-scale multimodal data integration, enabling increasingly accurate prediction of clinical outcomes and patient stratification. These systems, however, remain fundamentally observational: they learn statistical associations from historical data and operate within previously observed biological and clinical states, limiting their ability to generalize to novel therapies or unobserved interventions.\n  We argue that AI in biomedicine is undergoing a structural transition. As biomedical decision-making increasingly depends on reasoning about intervention rather than extrapolation from past observations, predictive architectures become structurally insufficient. Systems that learn from historical data cannot, by construction, represent how biological systems evolve under perturbation, and therefore cannot reliably support decision-making in the presence of novel","title":"From Prediction to Intervention: The Evolution of AI in Biomedicine","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-05-28T04:43:38Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2605.16293"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:11ad18b00a91fe686c1236e2b5d488c468cd1a5f2ab449f294866b7447eb167e15010c72eb613e1c2a5cd658d7562f60b188ef79846ad22773e77fda69e81801","signer":"crovia.substrate","subject":{"observed_at":"2026-05-28T04:43:38Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2605.16293"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"a3d938a08b2b2df90f0d255c88bae60009f7f7f622332af6b884bb746f9efc3a","leaf_index":156102,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"0049f54e9d477b3669fd53727ba5c8a9c9b3803d97cac8702b48e9b4cb1e5ee1","side":"right"},{"sibling":"20c962e4f5e8926fb4d344b83160159e27f81f832176c3db59947419ee357eaa","side":"left"},{"sibling":"159ee6c867307b60505dcdd1097442b0e7f858c9ff903a2184f265b5a31c1b64","side":"left"},{"sibling":"a12bb0e4fa8e3e1188e1bff716d7dbe632226367d7054a2e68334e3431040302","side":"right"},{"sibling":"3c96ec5758ed451bcd1e2ff505c7bb9418435c45d5dd060b4d35ea351744dc0f","side":"right"},{"sibling":"d9d45ad9e5409b3c85e60e917a3702b02c1bfe68c444ee6b4cd4538688fa6e2d","side":"right"},{"sibling":"393100346d5809dbed113e2610821a2f23e4d6e39003d6c00dfbc39fd409fe3f","side":"left"},{"sibling":"1edf9a008b98a304748398083d1a13a2c7d3eb3bd83b9b734c4d8e1ed72f9e97","side":"left"},{"sibling":"92ebfba9adaa779ba57179e1e0f933c2128036a29e48cb81e4e64272dbbbb5c0","side":"left"},{"sibling":"f292d3278e493ec60902181b8c0bd5c89c0a1168ef928222fe6161287982f7f0","side":"right"},{"sibling":"2209295faf1a5bf51c97c6fd5a839a8181a4ea44f490420381530f35df7d9b2f","side":"right"},{"sibling":"5784576a15214ea9fc3569e6e1cff1ef443c0b1fc0d036028489088af089de27","side":"right"},{"sibling":"311772ec218efcb2da5a337f9e9f042fe1cc0028643adb0a354787e4ea7911b7","side":"right"},{"sibling":"66331bac84ca0f8983eb09fac7eaf95af234f1b82680b793eabff4ee25caac40","side":"left"},{"sibling":"35ca36cee447f0ef7064a25d55f59357c66901e31427729c4c1d8b14aa8adb6c","side":"left"},{"sibling":"7b6f0bea4291a5e63574dfca9aa0f9756f450c9478c3d07474d39a7ababb51f9","side":"right"},{"sibling":"1d39fe14b21e2ebbfb87e882423b24ee9469eae1e4c77af5b799ac4db9537467","side":"right"},{"sibling":"d841ad93efda0869e5eb97678f348f03f5caab4353e05ff4bf18f47fb945b822","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":156177,"merkle_root":"c5705a0243d16afd8b1ebfd731b7aa304079c442c2a7906493c5bbed374c69ec","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260528T053701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-05-28T05:37:36Z","sig_algorithm":"ed25519","signature":"f087e13febc8bb6a2e0812610de64cebc65be92915518d9c4b230799c3b161839b04c4eb1b02741f938f35545a76ab76555b04c782bdc2f9a44852d171d65909","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_46a38ca8ad010081664a1de11cdc889fe2063707620b7a747fbaf4d538e3f441"}}