{"_canonicalization":{"envelope_id":"axm_ + sha256(envelope minus {signature, axiom_id, anchors})","envelope_signature":"ed25519(envelope minus {signature, axiom_id})","json":"sort_keys=True, separators=(',',':'), ensure_ascii=False, allow_nan=False, utf-8","leaf_hash":"sha256(0x00 || canonical_json(envelope_full))","seal_signature":"ed25519(seal minus {signature, sig_algorithm})"},"axiom_id":"axm_518e3cf86684198870a696d98ed1ee65aadd70b8f0b2111da0a8a1119c5cea08","bitcoin_anchor":{"bitcoin_attestations":["bitcoin_block_949451"],"calendar_attestations":["https://finney.calendar.eternitywall.com","https://btc.calendar.catallaxy.com","https://alice.btc.calendar.opentimestamps.org","https://bob.btc.calendar.opentimestamps.org"],"ots_url":"/registry/data/substrate/anchors/77fc9c28fae777b81da5b495b3115474df6592dfac590333213d3bdf8b94a9b3.ots","stamped_at":"2026-05-15T03:00:03Z","status":"bitcoin"},"envelope":{"anchors":[{"chain":"crovia.axiom_graph","height":0,"merkle_proof":"spider_vendor_press_v1","root_at_anchor":"spider_vendor_press_v1"}],"axiom_id":"axm_518e3cf86684198870a696d98ed1ee65aadd70b8f0b2111da0a8a1119c5cea08","axiom_type":"AX.OBS","body":{"axiom_subtype":"news.vendor_press.v1","category":"news","fingerprint":"74089699af9c3d51aa0afe4493e6d6fd234b2309b286dc9a5e9760ea04a2a072","published":"Tue, 12 May 2026 00:00:00 -0400","receipt_hash":"74089699af9c3d51aa0afe4493e6d6fd234b2309b286dc9a5e9760ea04a2a072","schema":"spider.news.vendor_press.v1","spider":"vendor_press","spider_record":{"axiom_subtype":"news.vendor_press.v1","category":"news","decision_hint":"POSITIVE","envelope_target":"AX.OBS","fingerprint":"74089699af9c3d51aa0afe4493e6d6fd234b2309b286dc9a5e9760ea04a2a072","observed_at":"2026-05-12T04:43:42.564879Z","parent_run_hash":"4cc5aca0c1b8116c9ab92405e0260204f01cf7ce2e49dea9d7e123236f5dc13b","published":"Tue, 12 May 2026 00:00:00 -0400","runtime_version":"0.1.0","schema":"spider.news.vendor_press.v1","source_status":200,"source_url":"https://export.arxiv.org/rss/cs.AI","spider":"vendor_press","summary_excerpt":"arXiv:2605.10876v1 Announce Type: cross \nAbstract: Recent advances in machine learning and large-scale biological data collections have revived the prospect of building a virtual cell, a computational model of cellular behavior that could accelerate biological discovery. One of the most compelling promises of this vision is the ability to perform in silico phenotypic screens, in which a model predicts the effects of cellular perturbations in unseen biological contexts. This task combines heterogeneous textual inputs with diverse phenotypic outputs, making it particularly well-suited to LLMs and agentic systems. Yet, no standard benchmark currently exists for this task, as existing efforts focus on narrower molecular readouts that are only indirectly aligned with the phenotypic endpoints driving many real-world drug discovery workflows. In this work, we present AssayBench, a benchmark for phenotypic screen prediction, built from 1,920 publicly available CRISPR screens spanning five broa","title":"AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents","url":"https://arxiv.org/abs/2605.10876","vendor":"arxiv_cs_ai"},"summary":"arXiv:2605.10876v1 Announce Type: cross \nAbstract: Recent advances in machine learning and large-scale biological data collections have revived the prospect of building a virtual cell, a computational model of cellular behavior that could accelerate biological discovery. One of the most compelling promises of this vision is the ability to perform in silico phenotypic screens, in which a model predicts the effects of cellular perturbations in unseen biological contexts. This task combines heterogeneous textual inputs with diverse phenotypic outputs, making it particularly well-suited to LLMs and agentic systems. Yet, no standard benchmark currently exists for this task, as existing efforts focus on narrower molecular readouts that are only indirectly aligned with the phenotypic endpoints driving many real-world drug discovery workflows. In this work, we present AssayBench, a benchmark for phenotypic screen prediction, built from 1,920 publicly available CRISPR screens spanning five broa","title":"AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-05-12T04:43:42Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2605.10876"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:b533ebc8efb3fa80ca054291dd48c7bfba7833ad538f888245a8aaed93011b3bf55deade700f988ad36c75c39f12f40827f5b887e340d9d4da7468bdac6d930a","signer":"crovia.substrate","subject":{"observed_at":"2026-05-12T04:43:42Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2605.10876"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"794434b4f1f9897f2fa9fe4cb354a2ca4724bbcccf8d27bedf66893b542e2bb8","leaf_index":128933,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"a157cf12f0cedaa82197110a9bfb997313a0201611c17e15d7a7add0349babdd","side":"left"},{"sibling":"892f97cb7e6f6301ce0366741226c11601dc770461ade8cab84eb0efb60b6731","side":"right"},{"sibling":"da98604ad619ad41e02357fbd2ab0dfd4d6f40ab2626459b574aea4d1241ac55","side":"left"},{"sibling":"a604a0d02fba6b80a897df8e063c2f8a7d9c36e4f3ef1b22a94779172ec1518f","side":"right"},{"sibling":"e23f3ce43388d4286e1c01a050ca8172eb887cd92bd05b49624d3a43b5acd350","side":"right"},{"sibling":"6aec6c64a8c51acafa3cd6f2510901a65685bb88a027ca6990ac432e2978b856","side":"left"},{"sibling":"c76bba0c216c73590d44e9b2dbdda205cb4803404f532bfebb832fe2ca20fafe","side":"right"},{"sibling":"5eb042446399e2602ae7dd8d9f9f2cac58abf22ff48527ae02c589594da10510","side":"left"},{"sibling":"9b7895252355a8c8a373671590682bbf4d36d41befce49b5e889eaf896415156","side":"left"},{"sibling":"1d74b0fb79eace68949b4d82b0e430b1d9eb122c125f67f5be7d50c074c228e7","side":"left"},{"sibling":"c6eaf7a4fcab2db96e9e9423acb6922c80f64882d0f3f50d09e53a4807d23084","side":"left"},{"sibling":"df12eaabc0a370aff5d0488478f48d2b3f90d025c903643f98ea804b017688ec","side":"right"},{"sibling":"ffc4d51379293bc3e1910c7d612f409dc610fd9acf8241793fb89f82e1bad4ef","side":"left"},{"sibling":"62ac6554017807bd83187f5a3e5f4f72d6c482616429c2780e9fff1f4845fa04","side":"left"},{"sibling":"3a5e69cf0803f4c91f3895ed7c9a95748fef240bec4422e167c05300f79f06c0","side":"left"},{"sibling":"f2817ab288b5324fe49770372c7a10f33f7cd11005f8d4c0a730316f5229dc98","side":"left"},{"sibling":"725fac972e772ca0dc598810ea1abc70df472f72d2d6ab8a0baee2b80e5d2f4c","side":"left"},{"sibling":"98fc57dfef8873b512edc8340f7181df57302bb96777625e072235c62d7c5895","side":"right"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":134292,"merkle_root":"77fc9c28fae777b81da5b495b3115474df6592dfac590333213d3bdf8b94a9b3","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260515T023701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-05-15T02:37:25Z","sig_algorithm":"ed25519","signature":"68107a834b00b24f5d4501e5ec727445311f132a486567ecc4c72a4e6dff24c8c21f2de3105293353ba5fdbe370d032819af6aa70f694e2e39b6af6737507009","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_518e3cf86684198870a696d98ed1ee65aadd70b8f0b2111da0a8a1119c5cea08"}}