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FIB-4 is widely used as a first-line non-invasive test, but its fixed formula may underuse diagnostic information contained in age, aspartate aminotransferase, alanine aminotransferase, and platelet count. We evaluated whether machine-learning-enhanced non-invasive testing (MLE-NIT) can improve advanced fibrosis detection while preserving this FIB-4 variable space.\n  We used three biopsy-confirmed MASLD cohorts from China, Malaysia, and India (n=784). The Chinese cohort was split into 486 training and 54 internal validation/tuning patients; final performance was reported only on the Malaysian and Indian external cohorts. Models used five variables: age, FIB-4, aspartate aminotransferase, platelet count, and alanine aminotransferase. We compared FIB-4 with a shallow-deep neural network (s-DNN), TabPFN,","title":"Machine-Learning-Enhanced Non-Invasive Testing for MASLD Fibrosis: Shallow-Deep Neural Networks Versus FIB-4, Tabular Foundation Models, and Large Language Models","url":"https://arxiv.org/abs/2605.20523","vendor":"arxiv_cs_ai"},"summary":"arXiv:2605.20523v1 Announce Type: cross \nAbstract: Advanced fibrosis is a major determinant of liver-related morbidity in metabolic dysfunction-associated steatotic liver disease (MASLD). FIB-4 is widely used as a first-line non-invasive test, but its fixed formula may underuse diagnostic information contained in age, aspartate aminotransferase, alanine aminotransferase, and platelet count. We evaluated whether machine-learning-enhanced non-invasive testing (MLE-NIT) can improve advanced fibrosis detection while preserving this FIB-4 variable space.\n  We used three biopsy-confirmed MASLD cohorts from China, Malaysia, and India (n=784). The Chinese cohort was split into 486 training and 54 internal validation/tuning patients; final performance was reported only on the Malaysian and Indian external cohorts. Models used five variables: age, FIB-4, aspartate aminotransferase, platelet count, and alanine aminotransferase. We compared FIB-4 with a shallow-deep neural network (s-DNN), TabPFN,","title":"Machine-Learning-Enhanced Non-Invasive Testing for MASLD Fibrosis: Shallow-Deep Neural Networks Versus FIB-4, Tabular Foundation Models, and Large Language Models","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-05-22T04:43:12Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2605.20523"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:18d656d520cde0fe1f59eac6bf64b08c776dd84659a8d8a35c26155dcb0bc540491f4afe23a676f04340abf6295ecedc4294586c0ef03714b6dd5de57b062506","signer":"crovia.substrate","subject":{"observed_at":"2026-05-22T04:43:12Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2605.20523"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"fe3c28dcbea582724e8d5e9bd9f3dd7228dfb79d4106f8b4aa3f6a5936c92a0d","leaf_index":148238,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"ef2833f8dfed918a6991ca6dcbca300777ed2cdb47e51d362674fe09bb41d4c6","side":"right"},{"sibling":"11e0cf60ea4ecbd2678943d1bae4740973f040c1b44883b2b590fa61ae37f9af","side":"left"},{"sibling":"11b90cb5c84e334275cc8910d6d33627daf6f45472aee76370f8a46a8bd1ce15","side":"left"},{"sibling":"99578c0f2febb14c913901c5691077dc743604924d6245421e3ec3d0e76d0be5","side":"left"},{"sibling":"4719d72db3535b04c69a3b1a92eaf8b76e4ae41300132f462730e0f36d72e2bf","side":"right"},{"sibling":"0cdd6f74518a78e2d51c6d1c6d14d0688bc4da61583f7df49842f7924f36305e","side":"right"},{"sibling":"2f67ce1ca4d405b588b0534baed360bc76fbba6b3678854914e0889a47207afb","side":"right"},{"sibling":"0fa191199f785899b5cc0f48838a3ffb2aa741ddcd9510fe1664869d36a8d31a","side":"right"},{"sibling":"e6aaada16cbe58b790855c6723700fd07821cc6df59048dc470d404b1ba60842","side":"left"},{"sibling":"d337a9fdcfc121e9691d8db9173af6a3fe0c33d4a6d5f0c8a7a01af04f9fb856","side":"left"},{"sibling":"8b39e07457f5cc5d687d2ae42284dbe705bb87084e7db4b626aff81e51dacd19","side":"right"},{"sibling":"79a713e1e345ccb99c5fe994a11708c8e9bcfa2e91f940d70421cb7d8d77ecc6","side":"right"},{"sibling":"249870fb494bef050c409081e5de45f9042938d7b2823524ee496f296aa63667","side":"right"},{"sibling":"96c48ee8328f1b7925a4cc4421df5cb0bd81c92a5d8354c93126fa5f0166d225","side":"right"},{"sibling":"35ca36cee447f0ef7064a25d55f59357c66901e31427729c4c1d8b14aa8adb6c","side":"left"},{"sibling":"4e13b4a3e69bb83d13913477a782913ce03937edd65046853c1964d3cbb6564b","side":"right"},{"sibling":"0f7b2df1c4580bf7bb7c24b9158ba20593a06af18a5f18d0973e5eff20c35cd8","side":"right"},{"sibling":"d841ad93efda0869e5eb97678f348f03f5caab4353e05ff4bf18f47fb945b822","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":148601,"merkle_root":"44900cffd986f40535c83f46a250e86fbf1019d41f27080a00fbf9b8d77ec33a","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260524T133701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-05-24T13:37:32Z","sig_algorithm":"ed25519","signature":"059e428c3c5241de303721ad6ac7b748758372180f3f0a717810312aecd6fab073abb3ea264157666de581a2b361c4c6e2aa8ca081b08ce9be090721f0e3400e","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_5e24a6e25bc6dc31ae2b020efba030cf4c8375461de8458e6ad60c4f22416295"}}