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Passive smartphone sensing offers a continuous, unobtrusive alternative, but prior sensing-based affect prediction has been limited by an accuracy ceiling, suggesting a bottleneck not only in available data, but in how behavioral signals are interpreted. We present PULSE, a system that shifts from fixed feature pipelines to agentic sensing investigation: LLM agents equipped with eight purpose-built tools autonomously query smartphone sensing data, compare current behavior against personalized baselines, and calibrate inferences through retrieval-augmented population-level comparisons. Rather than receiving pre-formatted feature summaries, agents decide which modalities to inspect, how far back to look, and how","title":"PULSE: Agentic Investigation with Passive Sensing for Proactive Intervention in Cancer Survivorship","url":"https://arxiv.org/abs/2605.17679","vendor":"arxiv_cs_ai"},"summary":"arXiv:2605.17679v1 Announce Type: cross \nAbstract: Cancer survivors face elevated rates of depression, anxiety, and general emotional distress, yet the precise moments they most need support are often the moments when self-report is sparse, a phenomenon we term the diary paradox. Passive smartphone sensing offers a continuous, unobtrusive alternative, but prior sensing-based affect prediction has been limited by an accuracy ceiling, suggesting a bottleneck not only in available data, but in how behavioral signals are interpreted. We present PULSE, a system that shifts from fixed feature pipelines to agentic sensing investigation: LLM agents equipped with eight purpose-built tools autonomously query smartphone sensing data, compare current behavior against personalized baselines, and calibrate inferences through retrieval-augmented population-level comparisons. 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