{"_canonicalization":{"envelope_id":"axm_ + sha256(envelope minus {signature, axiom_id, anchors})","envelope_signature":"ed25519(envelope minus {signature, axiom_id})","json":"sort_keys=True, separators=(',',':'), ensure_ascii=False, allow_nan=False, utf-8","leaf_hash":"sha256(0x00 || canonical_json(envelope_full))","seal_signature":"ed25519(seal minus {signature, sig_algorithm})"},"axiom_id":"axm_6e487d2415c35938e1faa89c7c8364c2c06df672226abde19cafc6b8601044f5","bitcoin_anchor":{"bitcoin_attestations":[],"calendar_attestations":[],"ots_url":"","stamped_at":"","status":"pending_next_stamp"},"envelope":{"anchors":[{"chain":"crovia.axiom_graph","height":0,"merkle_proof":"spider_vendor_press_v1","root_at_anchor":"spider_vendor_press_v1"}],"axiom_id":"axm_6e487d2415c35938e1faa89c7c8364c2c06df672226abde19cafc6b8601044f5","axiom_type":"AX.OBS","body":{"axiom_subtype":"news.vendor_press.v1","category":"news","fingerprint":"b5a8e161f1051078e440ba6f6db830b7be74f603ca703844e780a516689fc449","published":"Tue, 30 Jun 2026 00:00:00 -0400","receipt_hash":"b5a8e161f1051078e440ba6f6db830b7be74f603ca703844e780a516689fc449","schema":"spider.news.vendor_press.v1","spider":"vendor_press","spider_record":{"axiom_subtype":"news.vendor_press.v1","category":"news","decision_hint":"POSITIVE","envelope_target":"AX.OBS","fingerprint":"b5a8e161f1051078e440ba6f6db830b7be74f603ca703844e780a516689fc449","observed_at":"2026-06-30T04:43:04.087680Z","parent_run_hash":"74f7ab392cc702044101fe24a76a2fdad11164cd79ce725aad6c446a477e89c5","published":"Tue, 30 Jun 2026 00:00:00 -0400","runtime_version":"0.1.0","schema":"spider.news.vendor_press.v1","source_status":200,"source_url":"https://export.arxiv.org/rss/cs.AI","spider":"vendor_press","summary_excerpt":"arXiv:2606.28362v1 Announce Type: cross \nAbstract: Systematic reviews and meta-analyses (SR/MA) remain the gold standard for evidence synthesis, yet completing one typically requires 67 weeks and substantial expert effort. Recent large language model (LLM) systems have demonstrated strong performance on individual SR phases - screening (otto-SR: 96.7% sensitivity), extraction (Gartlehner et al.: 91.0% accuracy), and search (TrialMind: 0.83 recall) - but no study has reported what it actually costs to run an end-to-end pipeline, how cost distributes across phases, or how architectural choices affect the cost-quality trade-off. We present LUMEN, an open-source multi-agent pipeline that automates six SR/MA phases using 11 specialized LLM agents with deliberate model routing. We evaluate LUMEN on seven datasets: five self-conducted domain reviews (psychiatry, psychology, surgery, vaccinology, cardiology) and two SYNERGY screening benchmarks. Across 13 ground-truth-comparable outcomes, LUME","title":"LUMEN: Cost-Transparent Multi-Agent Pipeline for Automated Systematic Review and Meta-Analysis","url":"https://arxiv.org/abs/2606.28362","vendor":"arxiv_cs_ai"},"summary":"arXiv:2606.28362v1 Announce Type: cross \nAbstract: Systematic reviews and meta-analyses (SR/MA) remain the gold standard for evidence synthesis, yet completing one typically requires 67 weeks and substantial expert effort. Recent large language model (LLM) systems have demonstrated strong performance on individual SR phases - screening (otto-SR: 96.7% sensitivity), extraction (Gartlehner et al.: 91.0% accuracy), and search (TrialMind: 0.83 recall) - but no study has reported what it actually costs to run an end-to-end pipeline, how cost distributes across phases, or how architectural choices affect the cost-quality trade-off. We present LUMEN, an open-source multi-agent pipeline that automates six SR/MA phases using 11 specialized LLM agents with deliberate model routing. We evaluate LUMEN on seven datasets: five self-conducted domain reviews (psychiatry, psychology, surgery, vaccinology, cardiology) and two SYNERGY screening benchmarks. Across 13 ground-truth-comparable outcomes, LUME","title":"LUMEN: Cost-Transparent Multi-Agent Pipeline for Automated Systematic Review and Meta-Analysis","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-06-30T04:43:04Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2606.28362"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:89586ea622c82ed6ce71703c6f0438c5942d024c160ccb0b4ef809686f8a94af5c7421332c2fd56337f003b59ed8786835816369cd2107dced538c87f5c1dc00","signer":"crovia.substrate","subject":{"observed_at":"2026-06-30T04:43:04Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2606.28362"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"370018f18b017240f5d75489168358077792ed4e52f835f87da12543b36ffd55","leaf_index":264738,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"5a163f94065920cc0d75a91e5a4e7b547358ca17d3605acec437cb59eb00650c","side":"right"},{"sibling":"826c14b13faa728236ff9d29d6ab26bd44e5d52bfaac144aa2f1115be1330bbd","side":"left"},{"sibling":"4b8706ee20f175f6c1075941e0537de4db3f0aaf90d0ccae9a6f399a770b51b6","side":"right"},{"sibling":"c712d247fe9733d6b8701ecc7da2fb03bdf79e56804cf1a179adf3a92d1ce5e8","side":"right"},{"sibling":"2f1a26b7ce9e90bff1ae64f95b8808ce31c3c59b94e3be33dc8131def86be428","side":"right"},{"sibling":"62c2511acbb28aabfcaba7ed216a7ee083f7267ae54a2cb2ac52ee31c2ee5971","side":"left"},{"sibling":"fd797c68e25484e3e8f533754dfe81f0b434efa0d9663f06f6c246092816c476","side":"right"},{"sibling":"92d25c86b5a938b3e074cf8fcb4a80258ab9ddd97e3e6db319711ef13e7bf528","side":"right"},{"sibling":"5767f14b55df4212d25ae2f52b8f3d4abff2555c65ba62935ed6cb0a8e617b43","side":"right"},{"sibling":"1549a8883ab3267f958dc2624919e40c65c82958b8005967ed6a4da1247da0ad","side":"left"},{"sibling":"23994bf0974e5c9c7f63a61b4f0a48b0ca756a4adc34a8f85f878e774c37dfbe","side":"right"},{"sibling":"f9b4bed84fa6990c71ad2887c91bda183001f05f6b648f21d1273045a26b11fd","side":"left"},{"sibling":"173d2dc4b29ee04ea41d6d0ebc334c4bc2d46e7ee4230c94765413f24fb4bc42","side":"right"},{"sibling":"112461f7c0ec411116fb5c6c90fe95cea9d8f188b9fe08afe25a837ac02d0071","side":"right"},{"sibling":"ea9488204352c49db8f7daf05eefcd7628ecf9413830346674801a99d0654a94","side":"right"},{"sibling":"6261c13b9922cb657f10d1e5d36ec15d8771cf8766e36c61dcbffb7bed57e396","side":"right"},{"sibling":"fa19aa3faf287618b820bcfceebb366152ad521dd20ef9f51e977816663e448b","side":"right"},{"sibling":"c32f943406b62d1fc59b7f7e243492174c8e1caba8c8a2705f86c773315736e0","side":"right"},{"sibling":"1cecb7f447febd025aac272837c80de218aecc6485d2395a509b2a1f1b9c746e","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":265374,"merkle_root":"9636001ecab173cb6af10dc7c71eb14585daa62f9c0a6f027046f05633156891","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260630T053701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-06-30T05:38:03Z","sig_algorithm":"ed25519","signature":"6d4b8fd9b9da856cbb5fba7540877c6a63fa18a5ec3eaf28dc4d6d1c64921c9c0565f8c95f4b7aec0e7744fd7754844f051baf863db708cad768765b416a7b0c","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_6e487d2415c35938e1faa89c7c8364c2c06df672226abde19cafc6b8601044f5"}}