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Currently, there is a lack of theorizing regarding interactions with GSAs, and likewise, few guidelines exist for studying how they influence user attitudes and behaviors. Consequently, we propose the Knowledge-based Persuasion Model (KPM) as a novel theoretical framework. According to the KPM, a GSA's self-, user-, and context-knowledge drives its persuasive behavior, which in turn shapes attitudes and behaviors of a responding human user. Building on existing research, the model offers a structured approach to studying interactions with GSAs, supporting the development of agents that motivate rather than manipulate human users. Accordingly, the KPM encourages the integration of responsible GSAs that adhere to social norms and ethical standards with the goal of increasing user wellbeing. 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Building on existing research, the model offers a structured approach to studying interactions with GSAs, supporting the development of agents that motivate rather than manipulate human users. Accordingly, the KPM encourages the integration of responsible GSAs that adhere to social norms and ethical standards with the goal of increasing user wellbeing. 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