{"_canonicalization":{"envelope_id":"axm_ + sha256(envelope minus {signature, axiom_id, anchors})","envelope_signature":"ed25519(envelope minus {signature, axiom_id})","json":"sort_keys=True, separators=(',',':'), ensure_ascii=False, allow_nan=False, utf-8","leaf_hash":"sha256(0x00 || canonical_json(envelope_full))","seal_signature":"ed25519(seal minus {signature, sig_algorithm})"},"axiom_id":"axm_7a0eab0328815947506fc2f139b56bb1199e780920c0ee030b058d7b73555142","bitcoin_anchor":{"bitcoin_attestations":[],"calendar_attestations":[],"ots_url":"","stamped_at":"","status":"pending_next_stamp"},"envelope":{"anchors":[{"chain":"crovia.axiom_graph","height":0,"merkle_proof":"spider_vendor_press_v1","root_at_anchor":"spider_vendor_press_v1"}],"axiom_id":"axm_7a0eab0328815947506fc2f139b56bb1199e780920c0ee030b058d7b73555142","axiom_type":"AX.OBS","body":{"axiom_subtype":"news.vendor_press.v1","category":"news","fingerprint":"e6f1e32375618bf5912de25883505da1135bca0f6340a78ce2619d60f2f0d340","published":"Wed, 03 Jun 2026 00:00:00 -0400","receipt_hash":"e6f1e32375618bf5912de25883505da1135bca0f6340a78ce2619d60f2f0d340","schema":"spider.news.vendor_press.v1","spider":"vendor_press","spider_record":{"axiom_subtype":"news.vendor_press.v1","category":"news","decision_hint":"POSITIVE","envelope_target":"AX.OBS","fingerprint":"e6f1e32375618bf5912de25883505da1135bca0f6340a78ce2619d60f2f0d340","observed_at":"2026-06-03T04:43:57.136784Z","parent_run_hash":"62ae9c8eda846b00bc49666345b338d00756c5203438666c4c1fc694cc364b84","published":"Wed, 03 Jun 2026 00:00:00 -0400","runtime_version":"0.1.0","schema":"spider.news.vendor_press.v1","source_status":200,"source_url":"https://export.arxiv.org/rss/cs.AI","spider":"vendor_press","summary_excerpt":"arXiv:2606.02618v1 Announce Type: cross \nAbstract: We present Cognitive Loop via In-Situ Optimization (CLIO), an agent that couples a continuously-updated belief-state graph with a recursive plan-then-act loop. The result is a reasoning agent that can contribute something qualitatively different, which we term \\emph{calibrated deference}: the capacity to recognize when its own tools or assumptions are failing, to adapt its strategy in response, and to generate mechanistic hypotheses that guide experimental revision. We tested CLIO in a closed-loop human-AI campaign to design an aqueous organic redox flow battery (AORFB) negolyte, with CLIO leading proposal and interpretation in close partnership with chemists who synthesized, characterized, and weighed in on design choices. Across 17 candidates over three rounds, CLIO converged on a top phosphonate candidate; characterization confirmed a 130~mV improvement in redox potential over the literature baseline. Characterization then revealed ","title":"Closed-Loop Molecular Design with Calibrated Deference","url":"https://arxiv.org/abs/2606.02618","vendor":"arxiv_cs_ai"},"summary":"arXiv:2606.02618v1 Announce Type: cross \nAbstract: We present Cognitive Loop via In-Situ Optimization (CLIO), an agent that couples a continuously-updated belief-state graph with a recursive plan-then-act loop. The result is a reasoning agent that can contribute something qualitatively different, which we term \\emph{calibrated deference}: the capacity to recognize when its own tools or assumptions are failing, to adapt its strategy in response, and to generate mechanistic hypotheses that guide experimental revision. We tested CLIO in a closed-loop human-AI campaign to design an aqueous organic redox flow battery (AORFB) negolyte, with CLIO leading proposal and interpretation in close partnership with chemists who synthesized, characterized, and weighed in on design choices. Across 17 candidates over three rounds, CLIO converged on a top phosphonate candidate; characterization confirmed a 130~mV improvement in redox potential over the literature baseline. Characterization then revealed ","title":"Closed-Loop Molecular Design with Calibrated Deference","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-06-03T04:43:57Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2606.02618"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:bbf35be778bf66f4859c77d2813205a7802eb4ba9c239cf679782b4a080ba91af63a890f0444ef9542a656c5603c04e41094cab8816196a7f3ef70fad81a6205","signer":"crovia.substrate","subject":{"observed_at":"2026-06-03T04:43:57Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2606.02618"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"4ce7f9178bedda29c57a35ad94ebf4101e92164db44e50c1e405b03c43946502","leaf_index":209103,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"660d89267745a212fbe13429d2f1a807921df3081b0106910cc0837c7c682501","side":"left"},{"sibling":"43031d701682946aaa08c32b0fec74cf75b6effcc3035eb5c6c858cc28a2b877","side":"left"},{"sibling":"47d22753b0c592717717a0c1ef49dc509a6ebe4f9d9dbb8956c0d25b2876ed05","side":"left"},{"sibling":"8978b107a4e671b4a2becdf3dbad53ab8f48dc0006d179ad86f760ecb89dc65e","side":"left"},{"sibling":"3c64fcb507590b84b50ec7a7d47722c8c63a8f5717b468948582d5170b662600","side":"right"},{"sibling":"bbdc8533c8d8f5855c286968ddba9512cfc688ba8c32f801c9d86fbbeecf349b","side":"right"},{"sibling":"58746d6e8d96ba37e0b9e1ddb999eb39960ac9fbb6fc73c81cf5ab9ec0405d1e","side":"left"},{"sibling":"eae7f3d160253f87d5f2b594663f65cef3187784faa6d32d0ec2a662c29c4d98","side":"left"},{"sibling":"9924ce3405008f0c3a3b79e9066c574929b10c2965e0cc083262d3ac8aae2cb3","side":"right"},{"sibling":"2abcec6d14b256f82b270a3141886de6129141dec525543607b760f02588a877","side":"right"},{"sibling":"2b6b45743f97ac502854e489ac38a3366f8ae7ede58a2728b45daadbf29e9d03","side":"right"},{"sibling":"a81babbd79ea0da9e030dd7f43bffb6519d214317decd50727bea4e78189d970","side":"right"},{"sibling":"2dca509b3eb767a47cf215d4315f230ce9103a76264412008ae23a349b519ef1","side":"left"},{"sibling":"24d1bb4b13e0e46131b27b70a48e65fcf4e2e14b95e3bb83ade821e9df530f6b","side":"left"},{"sibling":"8d3baa674a45fd8bc6d3e8d25298f4bec86c72fa8259d576c330d12955c7b4f7","side":"right"},{"sibling":"e32819d1eff909db08066d1703f2db3f091cddac19378b2c0c625ab11e3fdbc0","side":"right"},{"sibling":"c300cf0154c136afc09b1702a0be98f4ba5b6dc5cf57e8cc714ec1eaf4196eff","side":"left"},{"sibling":"d841ad93efda0869e5eb97678f348f03f5caab4353e05ff4bf18f47fb945b822","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":209569,"merkle_root":"c852efc8ad7dfffc196c71380f79e6398bcaf566974cbae7c9950b0f600d5bc8","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260603T053701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-06-03T05:37:57Z","sig_algorithm":"ed25519","signature":"1ca417607effc813341721cfdade0a2d2d4ba96a90d361dbc3e864b6991b90abc326ec41d9ba3e7110cc04adb29d7b8d95abea7ff2ab8c591b2f864ed7270c03","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_7a0eab0328815947506fc2f139b56bb1199e780920c0ee030b058d7b73555142"}}