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We propose OmniBioTwin, a System-of-Twinned-Systems (SoTS) framework that organizes HDTs as modular computational entities coupled through explicit interaction operators within a multi-layer network architecture. The framework comprises seven coordinated layers - spanning data integration, autonomous twin modeling, cross-scale coupling, temporal synchronization, and human-in-the-loop decision support. We demonstrate OmniBioTwin by instantiating a multiscale twin for glucagon-like peptide-1 (GLP-1) signaling pathways in Alzheimer's disease, illustrating how molecular, cellular, and organ-level twins can be composed and coupled within a unified system.","title":"OmniBioTwin: A System-of-Twinned-Systems Framework for Health Digital Twins","url":"https://arxiv.org/abs/2606.11264","vendor":"arxiv_cs_ai"},"summary":"arXiv:2606.11264v1 Announce Type: cross \nAbstract: Health digital twins (HDTs) promise patient-specific modeling and decision support but current approaches remain structurally fragmented: monolithic models that address a single organ or task lack cross-scale fidelity, while system-level twins lack generalizable architectural frameworks. We propose OmniBioTwin, a System-of-Twinned-Systems (SoTS) framework that organizes HDTs as modular computational entities coupled through explicit interaction operators within a multi-layer network architecture. The framework comprises seven coordinated layers - spanning data integration, autonomous twin modeling, cross-scale coupling, temporal synchronization, and human-in-the-loop decision support. We demonstrate OmniBioTwin by instantiating a multiscale twin for glucagon-like peptide-1 (GLP-1) signaling pathways in Alzheimer's disease, illustrating how molecular, cellular, and organ-level twins can be composed and coupled within a unified system.","title":"OmniBioTwin: A System-of-Twinned-Systems Framework for Health Digital Twins","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-06-11T04:43:37Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2606.11264"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:eeed49979605ec91b2889ad2abe45c63ef7aae73760cb88693994c1937c9087f1b0fd1700f1767d6b916acc11b0a4dfdfb4223a1728808610ce642be8596a10b","signer":"crovia.substrate","subject":{"observed_at":"2026-06-11T04:43:37Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2606.11264"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"518c32443cfbe2c6bb0fc68c6750ccbc7ec2c412ad117eebc08505adc954ac29","leaf_index":227383,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"a8bed8380510199ed4f9b3b06b44c9f349d7a910da750736d935f4a63f2f6af3","side":"left"},{"sibling":"8d6b8b0091cc3d37b3ca3735ca21a3175a7eaca251d484c5c7bfc00526f34996","side":"left"},{"sibling":"8d7bab9a4b0784012c4dbef3ccfcf1c248e770c3dee823ff9467cf634718ae83","side":"left"},{"sibling":"e9853ec28ba74da5e4acdad76aa5a28728858425052b350927f16265a81ccea1","side":"right"},{"sibling":"66b9323502223b1bc3915fe41db31eaa7d4978925dae37049de86c00a3e10856","side":"left"},{"sibling":"af13b87f3f60a427d3566291c1ee132243edd0857ef187e279f49821afe385c3","side":"left"},{"sibling":"98a196a185b8283495ee2af791dddabecad12b9667f3282e20e2ada5f5abd314","side":"right"},{"sibling":"a6d2c01df24bdf78d7a3a20470793a1585a197c5d8c3f07fc4049ed07458246d","side":"right"},{"sibling":"2cfac7f042209c8533c6031bddc4a83bc156e0595f1b28efefbda208904f338a","side":"right"},{"sibling":"04e399458c5b36988cae0bf1c6dbe1b01349003b15cb5aa43f95c55acffe4ec3","side":"right"},{"sibling":"1383228337d54218bd8e5563aebb0b0dfe15c5269e3d5138e64c261d6130a88b","side":"right"},{"sibling":"57cb49c192550231071a0bf53a0821da2f79c585ec6c8d0fc76cebd62ccd78b2","side":"left"},{"sibling":"cdb58f86163046d3b15f857b03372ec75e1ad9ea4548e086793d528b9eed364d","side":"left"},{"sibling":"533d82482604463aa4a281b9d8b85917b383b7c5f924b2b494039524c55e8797","side":"left"},{"sibling":"b2590791b920ca2a4ed39de126d2c0b1a10d9e7e62f572f12425f214e767b6e1","side":"left"},{"sibling":"6cea4964f32722eb370847c2f7c9d6a9f0622c239538b07e6815a59d6fd8d49c","side":"right"},{"sibling":"c300cf0154c136afc09b1702a0be98f4ba5b6dc5cf57e8cc714ec1eaf4196eff","side":"left"},{"sibling":"d841ad93efda0869e5eb97678f348f03f5caab4353e05ff4bf18f47fb945b822","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":228173,"merkle_root":"7e416202c0bfd759bd2eea4236713b403993d99793fe8badb5065040080bece3","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260611T143708Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-06-11T21:59:35Z","sig_algorithm":"ed25519","signature":"231c80024bc3982dd493c45b31af95097e97aabc6d712a4e5bad7d0cbdd3c08e01ff395b0f8e72754bac97016e0cd0eed88b8a13cb71edbbcb9b6d72c10a7b03","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_810bd1721e1f2ac8dba1a9df7cc2660815eba9c2e704792de53ee1a00c13b35b"}}