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But how does this recipe transfer to dexterous manipulation? The answer is not obvious, as manipulation involves complex, contact-rich dynamics and requires delicate regulation of contact modes and forces. We present REGRIND, a minimalist retargeting-guided RL pipeline that learns dexterous manipulation policies from a single human demonstration. REGRIND retargets human hand-object motion to a robot reference that preserves hand-object spatial and contact relationships, trains a residual RL policy in simulation to track object-centric keypoints along that reference, and transfers the resulting policy zero-shot to hardware with careful system identification. 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REGRIND retargets human hand-object motion to a robot reference that preserves hand-object spatial and contact relationships, trains a residual RL policy in simulation to track object-centric keypoints along that reference, and transfers the resulting policy zero-shot to hardware with careful system identification. 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