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Its efficiency depends on the communication and computation latencies of the GPUs, which are linked to the placement of experts in the GPUs. Existing works for optimizing expert placement focus on leveraging past requests' expert activation patterns. However, they demonstrate deficiencies facing diverse and rapidly changing request patterns, calling for an online, proactive approach. Implementing such an approach requires addressing several challenges: the uncertainty associated with incoming requests' expert activation, the cost of expert migration, and the NP-hard complexity in optimization. Therefore, we present Director, a new distributed MoE serving system that minimizes end-to-end latency via prediction-driven, online expert placement. 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