{"_canonicalization":{"envelope_id":"axm_ + sha256(envelope minus {signature, axiom_id, anchors})","envelope_signature":"ed25519(envelope minus {signature, axiom_id})","json":"sort_keys=True, separators=(',',':'), ensure_ascii=False, allow_nan=False, utf-8","leaf_hash":"sha256(0x00 || canonical_json(envelope_full))","seal_signature":"ed25519(seal minus {signature, sig_algorithm})"},"axiom_id":"axm_a413c479b7580e59ea1b4443129f7999adfa0a2abb4cc2ef1ad304c1e3270769","bitcoin_anchor":{"bitcoin_attestations":[],"calendar_attestations":[],"ots_url":"","stamped_at":"","status":"pending_next_stamp"},"envelope":{"anchors":[{"chain":"crovia.axiom_graph","height":0,"merkle_proof":"spider_vendor_press_v1","root_at_anchor":"spider_vendor_press_v1"}],"axiom_id":"axm_a413c479b7580e59ea1b4443129f7999adfa0a2abb4cc2ef1ad304c1e3270769","axiom_type":"AX.OBS","body":{"axiom_subtype":"news.vendor_press.v1","category":"news","fingerprint":"cb76d8c7ee2addb1aaa491299ceb97851dca60fa1bc1913ec2097acc364406a0","published":"Fri, 22 May 2026 00:00:00 -0400","receipt_hash":"cb76d8c7ee2addb1aaa491299ceb97851dca60fa1bc1913ec2097acc364406a0","schema":"spider.news.vendor_press.v1","spider":"vendor_press","spider_record":{"axiom_subtype":"news.vendor_press.v1","category":"news","decision_hint":"POSITIVE","envelope_target":"AX.OBS","fingerprint":"cb76d8c7ee2addb1aaa491299ceb97851dca60fa1bc1913ec2097acc364406a0","observed_at":"2026-05-22T04:43:12.593252Z","parent_run_hash":"dd4d56660d55b2d65dc84dc5e7c8f83487d90da2dd343b5707d6948a3bb0d917","published":"Fri, 22 May 2026 00:00:00 -0400","runtime_version":"0.1.0","schema":"spider.news.vendor_press.v1","source_status":200,"source_url":"https://export.arxiv.org/rss/cs.AI","spider":"vendor_press","summary_excerpt":"arXiv:2604.27195v2 Announce Type: replace \nAbstract: Accurate prediction of conversion from Mild Cognitive Impairment (MCI) to Alzheimers Diseases (AD) is essential for early intervention, however, developing reliable conversion predictive models is difficult to develop due to limited longitudinal data availability We evaluate TabPFN (Tabular Pre-Trained Foundation Network) against traditional machine learning methods for predicting 3 year MCI to AD conversion using the TADPOLE dataset derived from ADNI. Using multimodal biomarker features extracted from demographics, APOE4, MRI volumes, CSF markers, and PET imaging, we conducted an experimental comparison across varying training set sizes (N=50 to 1000) and models including XGBoost, Random Forest, LightGBM, and Logistic Regression. TabPFN achieved one the highest performance (AUC=0.892), outperforming LightGBM (AUC=0.860) and demonstrating advantages in low data settings. At N=50 training samples, TabPFN maintained strong AUC while th","title":"Evaluating TabPFN for Mild Cognitive Impairment to Alzheimer's Disease Conversion in Data Limited Settings","url":"https://arxiv.org/abs/2604.27195","vendor":"arxiv_cs_ai"},"summary":"arXiv:2604.27195v2 Announce Type: replace \nAbstract: Accurate prediction of conversion from Mild Cognitive Impairment (MCI) to Alzheimers Diseases (AD) is essential for early intervention, however, developing reliable conversion predictive models is difficult to develop due to limited longitudinal data availability We evaluate TabPFN (Tabular Pre-Trained Foundation Network) against traditional machine learning methods for predicting 3 year MCI to AD conversion using the TADPOLE dataset derived from ADNI. Using multimodal biomarker features extracted from demographics, APOE4, MRI volumes, CSF markers, and PET imaging, we conducted an experimental comparison across varying training set sizes (N=50 to 1000) and models including XGBoost, Random Forest, LightGBM, and Logistic Regression. TabPFN achieved one the highest performance (AUC=0.892), outperforming LightGBM (AUC=0.860) and demonstrating advantages in low data settings. At N=50 training samples, TabPFN maintained strong AUC while th","title":"Evaluating TabPFN for Mild Cognitive Impairment to Alzheimer's Disease Conversion in Data Limited Settings","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-05-22T04:43:12Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2604.27195"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:8f0259993de1e101818dc0e3ca3802f247d98a0ca33eaf9bd076fe24164d06ba340e03c1f2524b7ec03a21ba4de18c0306f74e7c33331638f68c38de38c34e0a","signer":"crovia.substrate","subject":{"observed_at":"2026-05-22T04:43:12Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2604.27195"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"6331f389fc6c290663d53722abe01d1976440043cd7a4bc41dbcb37fdb9d91f2","leaf_index":148379,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"c89e4327b752bce30bf21affd4a45abf32082dabce5d5df7154695d52949a426","side":"left"},{"sibling":"3b500b3343d500f6662b5012fb085eb25765c62149517f4f3f4181d290d8b57c","side":"left"},{"sibling":"87c9a3c74fbc44e98b3d358641a37a25b27fa521bd6837f0f0d8935442d8639d","side":"right"},{"sibling":"ade45dd3ecc945a2262b2f25495a7079b60bb8cd84dcdfac934ef0b25d9991ea","side":"left"},{"sibling":"7bb9ac9b475853f2115ebd752084b882f46fc6d88c5dd7657ba421d0cd29d4ed","side":"left"},{"sibling":"836c6896ff980436fb6c7cd88f63b1a73d197c662ba0ace326f9af0163643db9","side":"right"},{"sibling":"d979d0e885bad58634c9288bbaf923efc618f551d038106bf5bd6a83f6908ba8","side":"right"},{"sibling":"753da9fa5ffb91dd383318229c9999d218b1611b357943fc0739373f06f55d17","side":"left"},{"sibling":"e6aaada16cbe58b790855c6723700fd07821cc6df59048dc470d404b1ba60842","side":"left"},{"sibling":"d337a9fdcfc121e9691d8db9173af6a3fe0c33d4a6d5f0c8a7a01af04f9fb856","side":"left"},{"sibling":"8b39e07457f5cc5d687d2ae42284dbe705bb87084e7db4b626aff81e51dacd19","side":"right"},{"sibling":"79a713e1e345ccb99c5fe994a11708c8e9bcfa2e91f940d70421cb7d8d77ecc6","side":"right"},{"sibling":"249870fb494bef050c409081e5de45f9042938d7b2823524ee496f296aa63667","side":"right"},{"sibling":"96c48ee8328f1b7925a4cc4421df5cb0bd81c92a5d8354c93126fa5f0166d225","side":"right"},{"sibling":"35ca36cee447f0ef7064a25d55f59357c66901e31427729c4c1d8b14aa8adb6c","side":"left"},{"sibling":"4e13b4a3e69bb83d13913477a782913ce03937edd65046853c1964d3cbb6564b","side":"right"},{"sibling":"0f7b2df1c4580bf7bb7c24b9158ba20593a06af18a5f18d0973e5eff20c35cd8","side":"right"},{"sibling":"d841ad93efda0869e5eb97678f348f03f5caab4353e05ff4bf18f47fb945b822","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":148601,"merkle_root":"44900cffd986f40535c83f46a250e86fbf1019d41f27080a00fbf9b8d77ec33a","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260524T133701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-05-24T13:37:32Z","sig_algorithm":"ed25519","signature":"059e428c3c5241de303721ad6ac7b748758372180f3f0a717810312aecd6fab073abb3ea264157666de581a2b361c4c6e2aa8ca081b08ce9be090721f0e3400e","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_a413c479b7580e59ea1b4443129f7999adfa0a2abb4cc2ef1ad304c1e3270769"}}