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We show that this baseline collapses to a 100% false-flag rate when the hazardous sequence comes from a taxonomic family absent from the reference set: under Conformal Risk Control's certified miss-rate constraint, a low-discrimination signal forces the threshold below the entire test-benign mass. We compose three signals derived from a synthesis order's public annotation: $k$-mer Jaccard similarity to known toxins, the trimmed-mean score of a five-LLM judge panel, and cosine similarity to clustered embedding centroids. Fused under a monotone logistic aggregator and calibrated by Conformal Risk Control, the resulting screener certifies $\\mathbb{E}[\\mathrm{FNR}] \\le \\alpha$. Across ten leave-one-taxonomic-family-out folds at $\\alpha=0.05$ on UniProt KW-0800 reviewed toxins, the calibrated screener achieves 0% test miss rate o","title":"CRC-Screen: Certified DNA-Synthesis Hazard Screening Under Taxonomic Shift","url":"https://arxiv.org/abs/2605.00074","vendor":"arxiv_cs_ai"},"summary":"arXiv:2605.00074v1 Announce Type: cross \nAbstract: DNA-synthesis providers screen incoming orders by searching the requested sequence against curated hazard lists. We show that this baseline collapses to a 100% false-flag rate when the hazardous sequence comes from a taxonomic family absent from the reference set: under Conformal Risk Control's certified miss-rate constraint, a low-discrimination signal forces the threshold below the entire test-benign mass. We compose three signals derived from a synthesis order's public annotation: $k$-mer Jaccard similarity to known toxins, the trimmed-mean score of a five-LLM judge panel, and cosine similarity to clustered embedding centroids. Fused under a monotone logistic aggregator and calibrated by Conformal Risk Control, the resulting screener certifies $\\mathbb{E}[\\mathrm{FNR}] \\le \\alpha$. Across ten leave-one-taxonomic-family-out folds at $\\alpha=0.05$ on UniProt KW-0800 reviewed toxins, the calibrated screener achieves 0% test miss rate o","title":"CRC-Screen: Certified DNA-Synthesis Hazard Screening Under Taxonomic Shift","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-05-05T04:43:28Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2605.00074"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:57596d58e02f9d68fc0b1efb384fce46a33b82184d18668b7deb93f3ccb6f61ab394876061b6fbb3461aff484378565c87212d6769a20847f3b114610b15fb03","signer":"crovia.substrate","subject":{"observed_at":"2026-05-05T04:43:28Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2605.00074"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"709f8ad0b5037523b9c6ae601336cef8004c988d51d3cf1f1500dc99a11c7174","leaf_index":114263,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"8c5d34851974122485ed47ebcd2c3498fde7d1b0727ab3c8ab55fb15899b9c38","side":"left"},{"sibling":"4818eb4fcce348e19087ad73b839f4ac5cf63169c28bea6b26003be10e1623c0","side":"left"},{"sibling":"f9ff04dc297e5a348a522730c7ea8568ad149daa90249abfe5702cd1486ba63d","side":"left"},{"sibling":"04a7586b6cc7d68aa01782b9eb9fed692aaffe019305250fdd1e1eb0aeac8507","side":"right"},{"sibling":"21063f2cf6c1befe98f4fb10e021f7a43b0a42a992065ad9c8b5fea8fe29b2a5","side":"left"},{"sibling":"a39a82c513a537c183ff1b16f330757a11afb374f0d12162ed010b9532d81bdd","side":"right"},{"sibling":"864ff8c61e24143ac1684572b26ed4ff162b3c2195104f55103383456befd161","side":"left"},{"sibling":"46dca532ded31bba3e38a2fc1bf625ddbe113eaf158d9999dfa7f7d5674bbb32","side":"right"},{"sibling":"17e21f83c86c2a86dddad911d22393ee81f41d8e0b79ef8c0c48668ea846f2ca","side":"right"},{"sibling":"8df6c69f776fbba620634f6baf125eeaa6fdf9426e461e649028010d9a703f42","side":"left"},{"sibling":"ea40d1bd0432ad4dd90f023c692aaab8c8f54e27ce652e82f2ec8e16cacfb632","side":"left"},{"sibling":"673cd6d27b696232f7f65e7a0733c7df6bc9fac3bcb569907ebb0de1c72c4bb2","side":"left"},{"sibling":"76d7c4385d71ae8104107105be66eddb792e01ed6e493db5a9b4eec5441abb76","side":"left"},{"sibling":"b03f005860bf95148ea89c703a32ca19ab7a2ca71b58bb628ff94a9edb8703b0","side":"left"},{"sibling":"21d1e30b556f553dc939fddc23e6367f0a7755ebe3dd489dc0001cef017beb7f","side":"right"},{"sibling":"f2817ab288b5324fe49770372c7a10f33f7cd11005f8d4c0a730316f5229dc98","side":"left"},{"sibling":"725fac972e772ca0dc598810ea1abc70df472f72d2d6ab8a0baee2b80e5d2f4c","side":"left"},{"sibling":"98fc57dfef8873b512edc8340f7181df57302bb96777625e072235c62d7c5895","side":"right"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":134292,"merkle_root":"77fc9c28fae777b81da5b495b3115474df6592dfac590333213d3bdf8b94a9b3","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260515T023701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-05-15T02:37:25Z","sig_algorithm":"ed25519","signature":"68107a834b00b24f5d4501e5ec727445311f132a486567ecc4c72a4e6dff24c8c21f2de3105293353ba5fdbe370d032819af6aa70f694e2e39b6af6737507009","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_a7ca91bb3a6ee7a40a85c3384a92cd570aef87890a04b256fcb9ea1fb697707f"}}