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This tradeoff becomes more complex when the classical control plane is degraded by cyber anomalies or denial-of-service traffic. We develop a CUDA-Q/SeQUeNCe co-simulation workflow for studying adaptive entanglement purification in heterogeneous linear repeater chains. CUDA-Q noisy quantum kernels are used to estimate primitive entanglement purification and swapping behavior, while SeQUeNCe provides an event-layer model for stochastic link generation, waiting-time-dependent memory decay, purification failure, and end-to-end swapping. Under stationary conditions, we compare no purification, local threshold purification, mean-field predictive purification, fixed purification, and a resource-penalized risk-aware predictive policy. 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