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A critical challenge here is ensuring the construct validity of generated items, i.e., whether they truly measure the intended trait. Traditionally, this requires costly, large-scale human data collection. To make it efficient, we present a framework for virtual respondent simulation using LLMs. Our central idea is to account for mediators: factors through which the same trait can give rise to varying responses to a survey item. By simulating respondents with diverse mediators, we identify survey items that yield responses robustly correlated with intended traits across these mediators. 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