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Recent learning-based and differentiable registration methods have shown promising accuracy, especially in patient-specific settings where abundant digitally reconstructed radiographs (DRRs) can be synthesized from the target CT. However, training a separate patient-specific model from scratch for every new patient is computationally inefficient and limits practical deployment. In this work, we propose an efficient patient-specific 2D/3D registration framework based on patient-agnostic synthetic pretraining and spherical similarity learning. The model is first pretrained on synthetic DRRs generated from multiple CT volumes to learn transferable pose-sensitive representations, and is then adapted to a new patient using only a limited number of synthetic projections from the ta","title":"Patient-Agnostic Synthetic Pretraining for Efficient Patient-Specific Intraoperative 2D/3D Registration","url":"https://arxiv.org/abs/2607.23343","vendor":"arxiv_cs_ai"},"summary":"arXiv:2607.23343v1 Announce Type: cross \nAbstract: Intraoperative 2D/3D registration aligns preoperative CT volumes with intraoperative X-ray or fluoroscopic images and is essential for image-guided interventions. Recent learning-based and differentiable registration methods have shown promising accuracy, especially in patient-specific settings where abundant digitally reconstructed radiographs (DRRs) can be synthesized from the target CT. However, training a separate patient-specific model from scratch for every new patient is computationally inefficient and limits practical deployment. In this work, we propose an efficient patient-specific 2D/3D registration framework based on patient-agnostic synthetic pretraining and spherical similarity learning. The model is first pretrained on synthetic DRRs generated from multiple CT volumes to learn transferable pose-sensitive representations, and is then adapted to a new patient using only a limited number of synthetic projections from the ta","title":"Patient-Agnostic Synthetic Pretraining for Efficient Patient-Specific Intraoperative 2D/3D Registration","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-07-28T04:43:08Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2607.23343"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:c634ca1d5b53f430595749e8193eb0ebb4dfdfa9e503e4b726d425ac3828f06097c6a9996e03e6e9e00cfc5810a97d3e4eb668b791b2ba78219bc69e14008f00","signer":"crovia.substrate","subject":{"observed_at":"2026-07-28T04:43:08Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2607.23343"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"c8a3c3d315bb8ab7bf35a27608b73c302df180b49bca2c4039b7d06905a2cbe5","leaf_index":360591,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"8f377cb80f5db3d833eb5b3c6ddd0ebdffc404f2e81f5a64332dd009177fcc81","side":"left"},{"sibling":"16ac9d9de8300d866efcbaab6de65897e804d2f8a02eac541cc8128c4885b2c2","side":"left"},{"sibling":"d60572515e401243b44e519fbbc2702bf30bb4c7cbda4437b982e9aad18ca8d9","side":"left"},{"sibling":"f45bcf0c87015db708765d2e7fff3b3a11d71004a3e06ac0f914835306e6fde2","side":"left"},{"sibling":"6a8047cb87adbc3eb747694dd7db1a951e69aee97dee42bad33b95ac97178e07","side":"right"},{"sibling":"1ef565bcfb1d01e26ff30da9c17f64918c8474ed53fe083d89b1fff6fd2a3035","side":"right"},{"sibling":"d519fc6bce16fe71e9292241b8844beed18a742eb10c7808343095fab2f059a2","side":"right"},{"sibling":"43776f432cc587f28ede8eaf5e1d4a4c47951623abe35c898f8f1127bf5ff870","side":"left"},{"sibling":"eb79f1d599c07786d2268140481af8b617999ecc5688c6283fe58e5e6f3a2640","side":"right"},{"sibling":"fe03c6d0b083c4097049d7fc6d7d08dfdb05d9c198b2786336689712d66eabf0","side":"right"},{"sibling":"590ea76fdfc1b9e8072055c378be3182f916709e8d06bd955232e650a7188b86","side":"right"},{"sibling":"d92781c59301ffd5bfb0bad75d9fdf6d73879f715518149d383f7362213e0daf","side":"right"},{"sibling":"f315303d4402b57497416d48eb4c4bb50405b40862d41c7caf318cb3d29c5237","side":"right"},{"sibling":"36973eb5f586cd67e0c0dc055dd87e734aa544c35d4400d2c9f932f8ef8fb27f","side":"right"},{"sibling":"e39f7900355489c4718b21cc2d3d06382e1d2f22b864d10be9ebc9d498b279a1","side":"right"},{"sibling":"1f9a970b25dd938c98cabc9e0a55c5a6f46292b9fa37cc89d90ef0cbb1e05a8c","side":"left"},{"sibling":"77025bcb374a7ad74f520643e20a8ae1205a7ee78507b0beb93117760f1c29d3","side":"left"},{"sibling":"3b50864499c874394ea0928567747666eaf59b01380e46cd52164ec5acec0f71","side":"right"},{"sibling":"1cecb7f447febd025aac272837c80de218aecc6485d2395a509b2a1f1b9c746e","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":361008,"merkle_root":"3065e8369ea437c06beba806dc4e4bb159979adeb21fe632242c1906a7204647","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260728T053701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-07-28T05:38:48Z","sig_algorithm":"ed25519","signature":"9141644407577a82611c1579110f667de2d46dc6b93c6322edf26f4c3056ea99f0e56502853908e30d87c38bcf95eb6e0ab5130525aa51505bd6f61938120609","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_b9af03e84d6898a758681eb4b395b3f3e956c499962449980d4b77223658da54"}}