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However, the scarcity of annotated CAG images with guidewires and the limited adaptability of existing guidewire synthesis models remain key bottlenecks for guidewire endpoint localization. To address this issue, we propose VDSB-GWSyn, a Diffusion Schr\\\"{o}dinger Bridge (DSB) model-based framework, enabling synthesis of controllable, high-fidelity guidewire samples under complex anatomical backgrounds. VDSB-GWSyn first uses our shape prior algorithm to learn the basic guidewire geometry. It then generates guidewire masks under constraints imposed by the vessel segmentation masks and outputs the corresponding endpoint coordinates. Finally, it synthesizes realistic guidewire samples on real CAG images using DSB conditioned with SP","title":"VDSB-GWSyn: Diffusion Schr\\\"{o}dinger Bridge for Controllable and Anatomically Feasible Guidewire Synthesis in Coronary Angiography","url":"https://arxiv.org/abs/2606.00109","vendor":"arxiv_cs_ai"},"summary":"arXiv:2606.00109v1 Announce Type: cross \nAbstract: Coronary guidewire endpoint localization is a fundamental capability for computer-assisted PCI, and its importance increases as robot-assisted PCI is progressively adopted to reduce operator radiation exposure. However, the scarcity of annotated CAG images with guidewires and the limited adaptability of existing guidewire synthesis models remain key bottlenecks for guidewire endpoint localization. To address this issue, we propose VDSB-GWSyn, a Diffusion Schr\\\"{o}dinger Bridge (DSB) model-based framework, enabling synthesis of controllable, high-fidelity guidewire samples under complex anatomical backgrounds. VDSB-GWSyn first uses our shape prior algorithm to learn the basic guidewire geometry. It then generates guidewire masks under constraints imposed by the vessel segmentation masks and outputs the corresponding endpoint coordinates. 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