{"_canonicalization":{"envelope_id":"axm_ + sha256(envelope minus {signature, axiom_id, anchors})","envelope_signature":"ed25519(envelope minus {signature, axiom_id})","json":"sort_keys=True, separators=(',',':'), ensure_ascii=False, allow_nan=False, utf-8","leaf_hash":"sha256(0x00 || canonical_json(envelope_full))","seal_signature":"ed25519(seal minus {signature, sig_algorithm})"},"axiom_id":"axm_bbf4c8849232872f915cb4aba93de040d5c3f9c827c642480844af62405055c4","bitcoin_anchor":{"bitcoin_attestations":[],"calendar_attestations":[],"ots_url":"","stamped_at":"","status":"pending_next_stamp"},"envelope":{"anchors":[{"chain":"crovia.axiom_graph","height":0,"merkle_proof":"spider_vendor_press_v1","root_at_anchor":"spider_vendor_press_v1"}],"axiom_id":"axm_bbf4c8849232872f915cb4aba93de040d5c3f9c827c642480844af62405055c4","axiom_type":"AX.OBS","body":{"axiom_subtype":"news.vendor_press.v1","category":"news","fingerprint":"7c70b79e600a31f4808ea339503aa4e9315595678891b3b851b946768bbd092f","published":"Tue, 26 May 2026 00:00:00 -0400","receipt_hash":"7c70b79e600a31f4808ea339503aa4e9315595678891b3b851b946768bbd092f","schema":"spider.news.vendor_press.v1","spider":"vendor_press","spider_record":{"axiom_subtype":"news.vendor_press.v1","category":"news","decision_hint":"POSITIVE","envelope_target":"AX.OBS","fingerprint":"7c70b79e600a31f4808ea339503aa4e9315595678891b3b851b946768bbd092f","observed_at":"2026-05-26T04:43:39.018238Z","parent_run_hash":"dca8dedd754ad6a1772113d6b97ee4f4ab9a0afbdeb44aaace5ff2d2446b164b","published":"Tue, 26 May 2026 00:00:00 -0400","runtime_version":"0.1.0","schema":"spider.news.vendor_press.v1","source_status":200,"source_url":"https://export.arxiv.org/rss/cs.AI","spider":"vendor_press","summary_excerpt":"arXiv:2603.00857v2 Announce Type: replace-cross \nAbstract: MultiPUFFIN is a domain-informed multimodal foundation model for predicting thermophysical properties of small molecules, addressing a critical gap in chemical engineering, drug discovery, and materials science. Existing molecular foundation models pretrain on millions of molecules to learn general-purpose representations, but their standard MLP output layers impose no physical constraints, vapor pressure predictions may violate monotonic temperature dependence, and viscosity curves may lack the functional form required by process simulators. Domain-informed approaches that guarantee thermodynamic consistency have remained limited to single properties and small datasets, whereas multimodal foundation models have focused on biological activity rather than thermophysical properties. MultiPUFFIN fills this gap by fusing SMILES sequences, 2D molecular graphs, and 3D conformer geometries through bidirectional cross-modal attention a","title":"MultiPUFFIN: A Multimodal Domain-Constrained Foundation Model for Molecular Property Prediction of Small Molecules","url":"https://arxiv.org/abs/2603.00857","vendor":"arxiv_cs_ai"},"summary":"arXiv:2603.00857v2 Announce Type: replace-cross \nAbstract: MultiPUFFIN is a domain-informed multimodal foundation model for predicting thermophysical properties of small molecules, addressing a critical gap in chemical engineering, drug discovery, and materials science. Existing molecular foundation models pretrain on millions of molecules to learn general-purpose representations, but their standard MLP output layers impose no physical constraints, vapor pressure predictions may violate monotonic temperature dependence, and viscosity curves may lack the functional form required by process simulators. Domain-informed approaches that guarantee thermodynamic consistency have remained limited to single properties and small datasets, whereas multimodal foundation models have focused on biological activity rather than thermophysical properties. MultiPUFFIN fills this gap by fusing SMILES sequences, 2D molecular graphs, and 3D conformer geometries through bidirectional cross-modal attention a","title":"MultiPUFFIN: A Multimodal Domain-Constrained Foundation Model for Molecular Property Prediction of Small Molecules","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-05-26T04:43:39Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2603.00857"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:d1a2e2348df2315812f93b442de466fb80c7aa44c09cbf3545994ff9ab0046e54ed69b943ff7a4f542c2d8c9a924e983b7d4ca4f99aae01808be2df349e5720e","signer":"crovia.substrate","subject":{"observed_at":"2026-05-26T04:43:39Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2603.00857"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"8a977b40f4aa49a1e718e8f9a6231880ded82a0a6da09088fe3a9aebb1055fd6","leaf_index":151962,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"4bd160b8f19ba55b8c65730afc79ca4017847a27ddff78388f83691f750f3208","side":"right"},{"sibling":"38e03eaba1f7d1e8abea968b8615839d7edfbf36e361d6852cb366e13ce7cbd1","side":"left"},{"sibling":"1d4e45b7b084cd217373dc847b79b635ffc5083c735366cf5e3131bf1b5a4f53","side":"right"},{"sibling":"ee389273dabb09e12b9084b260e0182b6ed5ded7d29d6a50289e106890aa316f","side":"left"},{"sibling":"bd78138f50c7c2cd7ea18c476126fa50e9d64c56fd172f68302e76b36ce87af6","side":"left"},{"sibling":"d343697805c8f4d7c4fdaed3423cc0b453fdf360c5ad7106d5f579c89d25631e","side":"right"},{"sibling":"6f1153ad830bc8202e6e1954981665e478138b53ce7dc91b62be904bade1d7fe","side":"right"},{"sibling":"8b0755e3ba26ea95e61e8d0e6362ce6cbe9991903d18e148b0cba214724147ec","side":"left"},{"sibling":"6c8b632bc887ad8683d2d08a66a66babfd1e8e43de4b1b760ed3f3d35d5b02e1","side":"left"},{"sibling":"879666fab72e779ab55d0564eaabd64b00534fd6bba7f18412c7f31f61ffd09f","side":"right"},{"sibling":"f40ccedd90c323817e961adc0a2e2db82b8aabe192b6c9d5a373ff988987b207","side":"right"},{"sibling":"b85ea61ae405eed84392a7b6b1eee5536f5a38d6b04070638e23ec7b71e3443a","side":"right"},{"sibling":"d415e6939aee710631f5062799379b547d2c3e3d9a68f263bbb5a693285ab2ca","side":"left"},{"sibling":"e5893793e3591ed7f5e58ca94ffcfba46bb30f69fb1c25d5ba8ef49eb99f9126","side":"right"},{"sibling":"35ca36cee447f0ef7064a25d55f59357c66901e31427729c4c1d8b14aa8adb6c","side":"left"},{"sibling":"e3eecaf996dbe7229a7bb1d234c97aea97a252c5f7c89f8547b6d091db0f0e40","side":"right"},{"sibling":"55bcbd4da3e20d93931f7e58673f10232e81a5b1514d7396cb4b71e8f95788d0","side":"right"},{"sibling":"d841ad93efda0869e5eb97678f348f03f5caab4353e05ff4bf18f47fb945b822","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":152106,"merkle_root":"ac5182c6f3dd09931f2a689df5f4be36df7b55e55bcf106e195671f5ed55fd8f","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260526T053701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-05-26T05:37:34Z","sig_algorithm":"ed25519","signature":"a401243fbd2c077d29a623c6ef616c78fbd5c8ce1930afa7af7165b2386e5a8cf15d5094983a1c962e71b27b911a3f3ce09c8cfab9393be2ce5ce8ee6513da06","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_bbf4c8849232872f915cb4aba93de040d5c3f9c827c642480844af62405055c4"}}