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However, most existing approaches rely on a single pathologist-selected slide, thereby discarding potentially informative evidence distributed across the remaining WSIs. To date, no autonomous framework has been proposed for comprehensive multi-WSI case processing. Here, we present an unsupervised framework for case-level analysis that integrates information from all available slides within a case. Rather than relying on a single designated slide, the proposed approach constructs case-level representations by selectively distilling informative patches across WSIs. We introduce Clustering-Based Redundancy-Reduced Instance Sampling for Pathology (CRISP), a two-stage framework that first reduces redundancy within individual WSIs and subsequentl","title":"CRISP -- Clustering-Based Redundancy-Reduced Instance Sampling for Pathology Case Representation and Retrieval","url":"https://arxiv.org/abs/2605.24253","vendor":"arxiv_cs_ai"},"summary":"arXiv:2605.24253v3 Announce Type: replace-cross \nAbstract: Digital pathology archives increasingly contain multiple whole-slide images (WSIs) per case, capturing spatially distinct tumor regions and reflecting intrinsic morphological heterogeneity. However, most existing approaches rely on a single pathologist-selected slide, thereby discarding potentially informative evidence distributed across the remaining WSIs. To date, no autonomous framework has been proposed for comprehensive multi-WSI case processing. Here, we present an unsupervised framework for case-level analysis that integrates information from all available slides within a case. Rather than relying on a single designated slide, the proposed approach constructs case-level representations by selectively distilling informative patches across WSIs. We introduce Clustering-Based Redundancy-Reduced Instance Sampling for Pathology (CRISP), a two-stage framework that first reduces redundancy within individual WSIs and subsequentl","title":"CRISP -- Clustering-Based Redundancy-Reduced Instance Sampling for Pathology Case Representation and Retrieval","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-06-03T04:43:57Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2605.24253"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:8b44bb7ed9c9d12656ef3cfec59cd11e81f75b954384ddeecfbc754d4e3751ca89a9442fe4e1ed946bedeeb12da6828cb8989fc51458e6d7d520cb700bdafc0e","signer":"crovia.substrate","subject":{"observed_at":"2026-06-03T04:43:57Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2605.24253"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"3ae95cc4509f9e79ff5a8724030dc885d413ca1e4a96c9af617ba0db457e63e2","leaf_index":209433,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"d8d4596fb1ad91532bae6067acdab843b8cff35d6618e9c3faa61ddd0e363f5c","side":"left"},{"sibling":"7eedb7787d4989d71a26658b57b85b7a76787227cf329af04b02ba014e5dacf1","side":"right"},{"sibling":"36688702566685f3ba8f725b3166a5ba42db82f3910436b7953c8c6c983baa23","side":"right"},{"sibling":"60430656ac10327cef51593160bb12c2119be127388ede7a0f6b418091e6bd18","side":"left"},{"sibling":"385a1c737c64457152f99ed56d2a68e3d6cf57bc6c9992e5c9092771c7a764e3","side":"left"},{"sibling":"d559fd51a6779addbcf4873e4b3f57dd068a0a4e618a552735f68c4c42472a78","side":"right"},{"sibling":"11ca635b4b48a5b191a023a3e865a6eb46cdcbad96ba62c238e770638277d969","side":"right"},{"sibling":"bd3f18ac9afb820a8496e447be39bc88ed2f38fc07726a205afbf4d7a97200b4","side":"right"},{"sibling":"5644262858e1dd0ce48f35fced719d068af594f17e93eb1cc769fc5838adcf49","side":"right"},{"sibling":"064aa099decb52d50f639e1542dae2860403f9fca4f561c55f796d74f4af6a83","side":"left"},{"sibling":"2b6b45743f97ac502854e489ac38a3366f8ae7ede58a2728b45daadbf29e9d03","side":"right"},{"sibling":"a81babbd79ea0da9e030dd7f43bffb6519d214317decd50727bea4e78189d970","side":"right"},{"sibling":"2dca509b3eb767a47cf215d4315f230ce9103a76264412008ae23a349b519ef1","side":"left"},{"sibling":"24d1bb4b13e0e46131b27b70a48e65fcf4e2e14b95e3bb83ade821e9df530f6b","side":"left"},{"sibling":"8d3baa674a45fd8bc6d3e8d25298f4bec86c72fa8259d576c330d12955c7b4f7","side":"right"},{"sibling":"e32819d1eff909db08066d1703f2db3f091cddac19378b2c0c625ab11e3fdbc0","side":"right"},{"sibling":"c300cf0154c136afc09b1702a0be98f4ba5b6dc5cf57e8cc714ec1eaf4196eff","side":"left"},{"sibling":"d841ad93efda0869e5eb97678f348f03f5caab4353e05ff4bf18f47fb945b822","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":209569,"merkle_root":"c852efc8ad7dfffc196c71380f79e6398bcaf566974cbae7c9950b0f600d5bc8","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260603T053701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-06-03T05:37:57Z","sig_algorithm":"ed25519","signature":"1ca417607effc813341721cfdade0a2d2d4ba96a90d361dbc3e864b6991b90abc326ec41d9ba3e7110cc04adb29d7b8d95abea7ff2ab8c591b2f864ed7270c03","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_c31b36ad977aeebf10258dddd247f1f9c23db0db3a4998218cb1ea7c7c27aef6"}}