{"_canonicalization":{"envelope_id":"axm_ + sha256(envelope minus {signature, axiom_id, anchors})","envelope_signature":"ed25519(envelope minus {signature, axiom_id})","json":"sort_keys=True, separators=(',',':'), ensure_ascii=False, allow_nan=False, utf-8","leaf_hash":"sha256(0x00 || canonical_json(envelope_full))","seal_signature":"ed25519(seal minus {signature, sig_algorithm})"},"axiom_id":"axm_d450dd119b2f0c9bf806342c1565e6cfea80ed0f6e429a03ef2031cd0c795d04","bitcoin_anchor":{"bitcoin_attestations":[],"calendar_attestations":[],"ots_url":"","stamped_at":"","status":"pending_next_stamp"},"envelope":{"anchors":[{"chain":"crovia.axiom_graph","height":0,"merkle_proof":"spider_vendor_press_v1","root_at_anchor":"spider_vendor_press_v1"}],"axiom_id":"axm_d450dd119b2f0c9bf806342c1565e6cfea80ed0f6e429a03ef2031cd0c795d04","axiom_type":"AX.OBS","body":{"axiom_subtype":"news.vendor_press.v1","category":"news","fingerprint":"12633883d39eed7f39ecf54c7455d58016cab983b552f6bb18895328290da8e4","published":"Sat, 06 Jun 2026 00:00:00 -0400","receipt_hash":"12633883d39eed7f39ecf54c7455d58016cab983b552f6bb18895328290da8e4","schema":"spider.news.vendor_press.v1","spider":"vendor_press","spider_record":{"axiom_subtype":"news.vendor_press.v1","category":"news","decision_hint":"POSITIVE","envelope_target":"AX.OBS","fingerprint":"12633883d39eed7f39ecf54c7455d58016cab983b552f6bb18895328290da8e4","observed_at":"2026-06-06T04:43:19.193968Z","parent_run_hash":"550d5b02674822f43975c282be668ca76a4d9c7c957eb1601ba8b07dcb67715e","published":"Sat, 06 Jun 2026 00:00:00 -0400","runtime_version":"0.1.0","schema":"spider.news.vendor_press.v1","source_status":200,"source_url":"https://export.arxiv.org/rss/cs.AI","spider":"vendor_press","summary_excerpt":"arXiv:2606.05925v1 Announce Type: new \nAbstract: A central goal of biomedicine is to understand, predict and ultimately control the dynamic mechanisms by which biological systems respond to perturbations, disease progression and therapeutic intervention. Although foundation models and large language models have accelerated biomedical data interpretation, most current systems remain focused on static pattern recognition rather than prospective simulation of biological futures. Here we propose biomedical world models as a paradigm for AI-driven discovery. These models learn latent representations of molecular, cellular, tissue and clinical states, together with intervention-conditioned dynamics that allow future trajectories to be simulated before actions are taken. We discuss how biomedical world models could function as data engines, environment simulators and scientific planning substrates across applications including virtual cells, organoids, virtual patients and surgical simulation","title":"Towards World Models in Biomedical Research","url":"https://arxiv.org/abs/2606.05925","vendor":"arxiv_cs_ai"},"summary":"arXiv:2606.05925v1 Announce Type: new \nAbstract: A central goal of biomedicine is to understand, predict and ultimately control the dynamic mechanisms by which biological systems respond to perturbations, disease progression and therapeutic intervention. Although foundation models and large language models have accelerated biomedical data interpretation, most current systems remain focused on static pattern recognition rather than prospective simulation of biological futures. Here we propose biomedical world models as a paradigm for AI-driven discovery. These models learn latent representations of molecular, cellular, tissue and clinical states, together with intervention-conditioned dynamics that allow future trajectories to be simulated before actions are taken. We discuss how biomedical world models could function as data engines, environment simulators and scientific planning substrates across applications including virtual cells, organoids, virtual patients and surgical simulation","title":"Towards World Models in Biomedical Research","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-06-06T04:43:19Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2606.05925"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:31f9b647a16110c69453c56a6219f1b1705a7a09b895e35f33e61719dcb7d8b0369ba6c05064650e75adebae0722dbcdf60a6db1e85592006d05f8a4655bd305","signer":"crovia.substrate","subject":{"observed_at":"2026-06-06T04:43:19Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2606.05925"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"f348b33ea18c61aec2e9447ad27301a0015299ae502b6503131818aa7e8754f2","leaf_index":219199,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"335d26cbcda041bd8c3ccb763d6c80b60a8ba7738da73139ceb1fc927fcc775d","side":"left"},{"sibling":"2c8fc87ed75647a59abab83a020c01115edd31f8ec49c0f389c40e9629ab7ae1","side":"left"},{"sibling":"143c2e47bb7e73b21d83083adaf9cef3574e9405ce06794a99eb09a710db50ac","side":"left"},{"sibling":"90ecfc81a82747efa78da9153f0d460910767fcfce7de4b59254f5d312e2cf9c","side":"left"},{"sibling":"f4869eed12dec42da7fc391990165e5592e3ad63dc4856ecb927050d480e7407","side":"left"},{"sibling":"6896b70f68725f0de91f11fd6d92e4eb931871fca1c6556881d67d3d75a00cc5","side":"left"},{"sibling":"ba0c0435014270951b6af7e23fbaff30fe8272fa4125f24fa90e4bbd06a8dd89","side":"right"},{"sibling":"8f35ffd1b994bec37a9cc24e0047790f92b64b006d85bef48f319d6d28a40687","side":"right"},{"sibling":"bd0dfa76bed61a2c5e95135a7304a2b8c4fd064958dbf768664232880d0abaa5","side":"right"},{"sibling":"84d2509eab51047589142ed6da8c496305d2fbcbe148e0e6755163db2c7a4bc4","side":"right"},{"sibling":"9e3ea17e834fab022f2eabcfedb8ea0ac95c1f9fb57edc5004dded68522d3c9e","side":"right"},{"sibling":"41d58fea95a95071715ee23ef8bcd15f5867a3639da28e62a0641bc95eb83094","side":"left"},{"sibling":"27ad9d6a9ab792d708709017242a61b9ca519da4e035f87a342811aae221d000","side":"left"},{"sibling":"5f303e2a7840c60038ff2d035b1cd911feefb0fba880de2d737c6671ace594d4","side":"right"},{"sibling":"b2590791b920ca2a4ed39de126d2c0b1a10d9e7e62f572f12425f214e767b6e1","side":"left"},{"sibling":"1a61eadbf0217d063ab78291ccafdc0c92907f7d6ccdc3357534ef89f07d78ae","side":"right"},{"sibling":"c300cf0154c136afc09b1702a0be98f4ba5b6dc5cf57e8cc714ec1eaf4196eff","side":"left"},{"sibling":"d841ad93efda0869e5eb97678f348f03f5caab4353e05ff4bf18f47fb945b822","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":219672,"merkle_root":"d3e32d3a61ca02ce6b1f0b2db86721107770b250e8a5bf762a2c225d2f03c870","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260606T053701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-06-06T05:38:35Z","sig_algorithm":"ed25519","signature":"dab214c2d4d857f01383c8e93a521a774b1aba60eaee5677d4e43e4074f0342b2c6a9b9bfcff0eba74f7ac81fcb490dd0e43727979c1a7e8979c7e11547fb101","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_d450dd119b2f0c9bf806342c1565e6cfea80ed0f6e429a03ef2031cd0c795d04"}}