{"_canonicalization":{"envelope_id":"axm_ + sha256(envelope minus {signature, axiom_id, anchors})","envelope_signature":"ed25519(envelope minus {signature, axiom_id})","json":"sort_keys=True, separators=(',',':'), ensure_ascii=False, allow_nan=False, utf-8","leaf_hash":"sha256(0x00 || canonical_json(envelope_full))","seal_signature":"ed25519(seal minus {signature, sig_algorithm})"},"axiom_id":"axm_d99d8dae742aeb60eff91513366390c79b42357bfbdfcf76c19bb965b683bd57","bitcoin_anchor":{"bitcoin_attestations":[],"calendar_attestations":[],"ots_url":"","stamped_at":"","status":"pending_next_stamp"},"envelope":{"anchors":[{"chain":"crovia.axiom_graph","height":0,"merkle_proof":"spider_vendor_press_v1","root_at_anchor":"spider_vendor_press_v1"}],"axiom_id":"axm_d99d8dae742aeb60eff91513366390c79b42357bfbdfcf76c19bb965b683bd57","axiom_type":"AX.OBS","body":{"axiom_subtype":"news.vendor_press.v1","category":"news","fingerprint":"416b11d4fe70ff79a35d5546a92dcc2eb00ca496bbcfe4ad47973e3518bbd965","published":"Tue, 07 Jul 2026 00:00:00 -0400","receipt_hash":"416b11d4fe70ff79a35d5546a92dcc2eb00ca496bbcfe4ad47973e3518bbd965","schema":"spider.news.vendor_press.v1","spider":"vendor_press","spider_record":{"axiom_subtype":"news.vendor_press.v1","category":"news","decision_hint":"POSITIVE","envelope_target":"AX.OBS","fingerprint":"416b11d4fe70ff79a35d5546a92dcc2eb00ca496bbcfe4ad47973e3518bbd965","observed_at":"2026-07-07T04:43:08.294902Z","parent_run_hash":"fc40a96e5d33ecc82922806c3ad18de4725d7af03964570396c8af4e48fb5bc1","published":"Tue, 07 Jul 2026 00:00:00 -0400","runtime_version":"0.1.0","schema":"spider.news.vendor_press.v1","source_status":200,"source_url":"https://export.arxiv.org/rss/cs.AI","spider":"vendor_press","summary_excerpt":"arXiv:2408.13378v5 Announce Type: replace \nAbstract: Workflows in drug-target interaction (DTI) assessment require integrating heterogeneous data from predictive models, curated resources, and observations from experimental literature. This evidence can be incomplete or conflicting. DrugAgent is a large language model (LLM)-based multi-agent system focused on DTI evidence integration that integrates outputs from machine learning, knowledge graph, and retrieval-augmented generation (RAG) agents. DrugAgent converts agent outputs into interpretable representations, then summarizes conflict across the evidence.\n  We evaluated DrugAgent on kinase screening data of 900 pairs spanning 178 kinases and 42 inhibitors, and an androgen receptor antagonist screening benchmark. On the kinase dataset, LLM-as-a-Judge evaluation indicated outputs were faithful to input evidence in 98.8% of cases. Biological plausibility of returned summarization was high (scores 3-4 out of 5) across ground-truth classe","title":"DrugAgent: Reliable Multi-Agent Integration of Conflicting Biomedical Evidence for Drug-Target Interaction Assessment","url":"https://arxiv.org/abs/2408.13378","vendor":"arxiv_cs_ai"},"summary":"arXiv:2408.13378v5 Announce Type: replace \nAbstract: Workflows in drug-target interaction (DTI) assessment require integrating heterogeneous data from predictive models, curated resources, and observations from experimental literature. This evidence can be incomplete or conflicting. DrugAgent is a large language model (LLM)-based multi-agent system focused on DTI evidence integration that integrates outputs from machine learning, knowledge graph, and retrieval-augmented generation (RAG) agents. DrugAgent converts agent outputs into interpretable representations, then summarizes conflict across the evidence.\n  We evaluated DrugAgent on kinase screening data of 900 pairs spanning 178 kinases and 42 inhibitors, and an androgen receptor antagonist screening benchmark. On the kinase dataset, LLM-as-a-Judge evaluation indicated outputs were faithful to input evidence in 98.8% of cases. Biological plausibility of returned summarization was high (scores 3-4 out of 5) across ground-truth classe","title":"DrugAgent: Reliable Multi-Agent Integration of Conflicting Biomedical Evidence for Drug-Target Interaction Assessment","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-07-07T04:43:08Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2408.13378"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:a4a2ac606c4a70604cde9035ebeaf87a609389f16cac0c7f713c7b571b44c8833b6299bf2ab1a0ce18805250fa02eaaa886eff9491edac7f8803808bf6c54d08","signer":"crovia.substrate","subject":{"observed_at":"2026-07-07T04:43:08Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2408.13378"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"6d5724f0f0de9491fdc3a0bd7e61f9a02ee4b34a746159bcff5e7d175238a1fe","leaf_index":289162,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"c8d3aea8cc05d02d351610971a879fb529b62cfdb1630a720f28f45697f00455","side":"right"},{"sibling":"f0834299e5c75715404d1daab2c4ccaaa478558720b6317d9032d538b37165c6","side":"left"},{"sibling":"b489d83de9e353e88e55f4a422b813da434eeb5cf52b0e5a405a2b0b954c3753","side":"right"},{"sibling":"29e5f916862738ad7143207ad23effa4c0a89f9e346d37ab307e7ef10018d4b5","side":"left"},{"sibling":"fb1dd078d487e954c1b3ba0a9b05a73fbfb563777928c60e8348e9934385d9b2","side":"right"},{"sibling":"5d89f664a906e8defe2abbe89c134df0a9bc15697f6b1ab4c1f1a61ad5a75bdf","side":"right"},{"sibling":"cfebf4e758f80b6c0a2520ffba9d9d900a232da3623a4c530a1c712d33cffc24","side":"right"},{"sibling":"a6e115fb6d42f8f126d042702270c371c7df6161120ef9b37366edddc165bd28","side":"left"},{"sibling":"35d3e8088ee93171aa479055dcd001cfb6d23925114ddc0908531e54298b0d29","side":"left"},{"sibling":"841129c21a7583176cdc7de281cadfe0e00d04673461e199760cd5128d8cc2d5","side":"right"},{"sibling":"19d6dfd29bc47f35fa02e8fe765277ba9cc3e6da5072309f24ebaac5b5f295e3","side":"right"},{"sibling":"8e0ad7889eb2d4b40e5b6c3d8e2eb19d4e202374983f468aa76321823de07a9f","side":"left"},{"sibling":"aae716235efcb893a1f219dbcd5095070d08a497769fc6d50c14976aa26d5750","side":"right"},{"sibling":"a75ab4319e241beeddb1b3f5705febe0422937926c3479923ccfb0b0082fa4e3","side":"left"},{"sibling":"bd04fa605f883bfb2b81510d045b1e85e555a03da3be083619f61384dfe40ff8","side":"left"},{"sibling":"1b72ad8d12164fdf329e7871711be99d8569d140b21f94056e6962da21da9ce1","side":"right"},{"sibling":"5f5109c2bfdcc7a7e70554bba25862e2d7ce86b6b0cd48a72eb66d2eb735f321","side":"right"},{"sibling":"05fd8a05dddb2e7f72bbb5b290ca55c378f1aed709f132277908d9a5f30eb605","side":"right"},{"sibling":"1cecb7f447febd025aac272837c80de218aecc6485d2395a509b2a1f1b9c746e","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":289613,"merkle_root":"dc428b9d9ba248d4f93f63147bf7c700bf5be7f500cec6c3507b9df6e9401601","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260707T053701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-07-07T05:38:15Z","sig_algorithm":"ed25519","signature":"c468b0e183383ab71992be40bda451093e6cd8cd8efb0d26f68e135a804b287c209d12a0f4fdd95c69c835c04b78df8cb1903dee1f53d4730b36f5332a29fe05","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_d99d8dae742aeb60eff91513366390c79b42357bfbdfcf76c19bb965b683bd57"}}