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We show that this baseline collapses to a 100% false-flag rate when the hazardous sequence comes from a taxonomic family absent from the reference set: under Conformal Risk Control's certified miss-rate constraint, a low-discrimination signal forces the threshold below the entire test-benign mass. We compose three signals derived from a synthesis order's public annotation: $k$-mer Jaccard similarity to known toxins, the trimmed-mean score of a five-LLM judge panel, and cosine similarity to clustered embedding centroids. Fused under a monotone logistic aggregator and calibrated by Conformal Risk Control, the resulting screener certifies $\\mathbb{E}[\\mathrm{FNR}] \\le \\alpha + \\mathrm{TV}$, where the additive term is the calibration-to-test distribution shift under family holdout (a certified ceiling of 24-49% across fo","title":"CRC-Screen: Certified DNA-Synthesis Hazard Screening Under Taxonomic Shift","url":"https://arxiv.org/abs/2605.00074","vendor":"arxiv_cs_ai"},"summary":"arXiv:2605.00074v2 Announce Type: replace-cross \nAbstract: DNA-synthesis providers screen incoming orders by searching the requested sequence against curated hazard lists. We show that this baseline collapses to a 100% false-flag rate when the hazardous sequence comes from a taxonomic family absent from the reference set: under Conformal Risk Control's certified miss-rate constraint, a low-discrimination signal forces the threshold below the entire test-benign mass. We compose three signals derived from a synthesis order's public annotation: $k$-mer Jaccard similarity to known toxins, the trimmed-mean score of a five-LLM judge panel, and cosine similarity to clustered embedding centroids. Fused under a monotone logistic aggregator and calibrated by Conformal Risk Control, the resulting screener certifies $\\mathbb{E}[\\mathrm{FNR}] \\le \\alpha + \\mathrm{TV}$, where the additive term is the calibration-to-test distribution shift under family holdout (a certified ceiling of 24-49% across fo","title":"CRC-Screen: Certified DNA-Synthesis Hazard Screening Under Taxonomic Shift","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-06-16T04:43:43Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2605.00074"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:934a89d54fbeb8dd62d311a3e09cf9874e8cc5b97940848f691e46c068475f3422fcfd5037320e055e76af1801a78a9f5adbd6327564b488ecfdb94c307f590d","signer":"crovia.substrate","subject":{"observed_at":"2026-06-16T04:43:43Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2605.00074"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"e221de64199977b955d77f089522130ad9cb35be9dc6175d1f53a5701cc0cd8f","leaf_index":230783,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"a498f968479963a1a3d7baadb97ac8ac65704075bb709138880b4feb01518606","side":"left"},{"sibling":"4afab938c9dbf11fcf3c2f87284bf903410e14f72f6ec282af4ad6684f4b830b","side":"left"},{"sibling":"5fbf1461ec0d4a8874ec9aefb3a8461412baba265195dd59c381b4dcdf085721","side":"left"},{"sibling":"c296845fe45e1a4f36dbe7407bad46e1864ea053e9add1ede8e53206ca3565b6","side":"left"},{"sibling":"57da84c31435f77ba4ff40ddb8b5099f00ea9e8c9d83e270f3db5c5178d8c921","side":"left"},{"sibling":"7aa99f4015dd98a0563d2e83c85dcca08e69f45621f90f181a6cfdfc410f527c","side":"left"},{"sibling":"b1e1df12b4e8ce1b08b9338eb3b267a37cae01cbfb702d871739c875eda9aed2","side":"left"},{"sibling":"7a295c86e2ca5719bf2e33d1fcc4bc631f05c6f31aeb907113e2c58401e3087c","side":"right"},{"sibling":"ee59602dad0bf74c97a32a93f0a1a19e7a12f2800791988a6fdf35611febe031","side":"left"},{"sibling":"0c5669692381d605223c74b8d30f70cd308e77e33d5e40ea84bb7b4f84f2d4d9","side":"right"},{"sibling":"d5b9f8b1a2c9f6a46e17982dfbe6ce1f3b5fa4e730220397f2253d114dcc8486","side":"left"},{"sibling":"d10d772a4984cae00e65ab24af21d1d260e475bbaae3f17871859eb705bd3999","side":"right"},{"sibling":"e79159853f2f35ddae8e3247d515e433c534277b287d65bbd77ae989aa4992fa","side":"right"},{"sibling":"3054319f1840cce0eaaf0bc4b1ae38e5bf8b6210927d924a750775cc7d77cca6","side":"right"},{"sibling":"0fd8b5059f279c4a4a6688de2472fdbc25543fee183df19b21dacca880354cff","side":"right"},{"sibling":"a04392fb9f2a3a620840e3b3fecd93d12e6d224e481c162389d8ae64e7194599","side":"left"},{"sibling":"c300cf0154c136afc09b1702a0be98f4ba5b6dc5cf57e8cc714ec1eaf4196eff","side":"left"},{"sibling":"d841ad93efda0869e5eb97678f348f03f5caab4353e05ff4bf18f47fb945b822","side":"left"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":232015,"merkle_root":"62bfb7809bb55667ad7eeebdb48267b9b2c1ee89bb808ea1e6d3a814a15aa402","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260617T133701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-06-17T13:39:59Z","sig_algorithm":"ed25519","signature":"930a3563c643cc7518d048b12a1f5392a96a5edce49533ba0a56f11b6cc69319bb1c800aacc46b52a6941c4d05dae255a45cac757d6093c971b96852c24f140e","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_e28e56152233fcb6db2cfd2f92e75460f782b89161e0d333a9157314fcec88de"}}