{"_canonicalization":{"envelope_id":"axm_ + sha256(envelope minus {signature, axiom_id, anchors})","envelope_signature":"ed25519(envelope minus {signature, axiom_id})","json":"sort_keys=True, separators=(',',':'), ensure_ascii=False, allow_nan=False, utf-8","leaf_hash":"sha256(0x00 || canonical_json(envelope_full))","seal_signature":"ed25519(seal minus {signature, sig_algorithm})"},"axiom_id":"axm_ed2d6506e189308d1b407783a78f4f29f627ad8289658cc045cf77fc127544cc","bitcoin_anchor":{"bitcoin_attestations":["bitcoin_block_949451"],"calendar_attestations":["https://finney.calendar.eternitywall.com","https://btc.calendar.catallaxy.com","https://alice.btc.calendar.opentimestamps.org","https://bob.btc.calendar.opentimestamps.org"],"ots_url":"/registry/data/substrate/anchors/77fc9c28fae777b81da5b495b3115474df6592dfac590333213d3bdf8b94a9b3.ots","stamped_at":"2026-05-15T03:00:03Z","status":"bitcoin"},"envelope":{"anchors":[{"chain":"crovia.axiom_graph","height":0,"merkle_proof":"spider_vendor_press_v1","root_at_anchor":"spider_vendor_press_v1"}],"axiom_id":"axm_ed2d6506e189308d1b407783a78f4f29f627ad8289658cc045cf77fc127544cc","axiom_type":"AX.OBS","body":{"axiom_subtype":"news.vendor_press.v1","category":"news","fingerprint":"2f01590dfd1c27224894f321c1d5135cf8ef1c28bdddc46d1b58bf138621a711","published":"Tue, 12 May 2026 00:00:00 -0400","receipt_hash":"2f01590dfd1c27224894f321c1d5135cf8ef1c28bdddc46d1b58bf138621a711","schema":"spider.news.vendor_press.v1","spider":"vendor_press","spider_record":{"axiom_subtype":"news.vendor_press.v1","category":"news","decision_hint":"POSITIVE","envelope_target":"AX.OBS","fingerprint":"2f01590dfd1c27224894f321c1d5135cf8ef1c28bdddc46d1b58bf138621a711","observed_at":"2026-05-12T04:43:42.564879Z","parent_run_hash":"4cc5aca0c1b8116c9ab92405e0260204f01cf7ce2e49dea9d7e123236f5dc13b","published":"Tue, 12 May 2026 00:00:00 -0400","runtime_version":"0.1.0","schema":"spider.news.vendor_press.v1","source_status":200,"source_url":"https://export.arxiv.org/rss/cs.AI","spider":"vendor_press","summary_excerpt":"arXiv:2605.08954v1 Announce Type: cross \nAbstract: Molecular optimization in drug discovery aims to discover molecules with improved target properties, but practical lead optimization often requires more than high predicted scores. A useful candidate should also be actionable: it should be reachable from known molecules through valid local structural transformations, so that it can be interpreted as a plausible revision within an evolving chemical series. Existing de novo and single-molecule optimization methods do not explicitly model such reachability, especially when both the target molecules and the intermediate molecules connecting them to known compounds are unknown. In this work, we formulate actionable molecular optimization as sequential expansion of a molecule-transfer graph, where nodes are molecules and edges encode valid local transformations. We propose MolWorld, a molecule world model-guided framework that treats the current molecule-transfer graph as an evolving search ","title":"MolWorld: Molecule World Models for Actionable Molecular Optimization","url":"https://arxiv.org/abs/2605.08954","vendor":"arxiv_cs_ai"},"summary":"arXiv:2605.08954v1 Announce Type: cross \nAbstract: Molecular optimization in drug discovery aims to discover molecules with improved target properties, but practical lead optimization often requires more than high predicted scores. A useful candidate should also be actionable: it should be reachable from known molecules through valid local structural transformations, so that it can be interpreted as a plausible revision within an evolving chemical series. Existing de novo and single-molecule optimization methods do not explicitly model such reachability, especially when both the target molecules and the intermediate molecules connecting them to known compounds are unknown. In this work, we formulate actionable molecular optimization as sequential expansion of a molecule-transfer graph, where nodes are molecules and edges encode valid local transformations. We propose MolWorld, a molecule world model-guided framework that treats the current molecule-transfer graph as an evolving search ","title":"MolWorld: Molecule World Models for Actionable Molecular Optimization","vendor":"arxiv_cs_ai"},"confidence":{"method":"deterministic"},"decision":"POSITIVE","issued_at":"2026-05-12T04:43:42Z","notes":"Spider vendor_press (news) news.vendor_press.v1","object":{"captured_by":"crovia.spider.vendor_press","primary_source_url":"https://arxiv.org/abs/2605.08954"},"predecessors":[],"schema":"crovia.axiom.v1","signature":"ed25519:98311e07cbed8aa369fe611fcda76232aff35ce49ad5b0cff4b52a6ee4d6fa157c067a62a2868400bbc9451fcbf004655d6babfa3ea54ddb864f46866e499203","signer":"crovia.substrate","subject":{"observed_at":"2026-05-12T04:43:42Z","source_collector":"spider:vendor_press","target_id":"https://arxiv.org/abs/2605.08954"},"tsa":{"authority":"crovia.substrate.bootstrap","rfc3161_token":"{\"kind\":\"crovia.bootstrap.tsa\",\"source_jsonl\":\"/opt/crovia/spider/data/news/vendor_press_v1.jsonl\",\"source_seal_merkle_root\":\"spider_vendor_press_v1\",\"upgrade_path\":\"Sessione H \\u2014 OpenTimestamps weekly anchor\"}"},"zk_mode":"clear","zk_proof":null},"ledger":{"leaf_hash":"396f20ad96af52a8b87904e6251159653716e348add148982fb6878476e1026c","leaf_index":128646,"ledger_path":"/opt/crovia/substrate/axiom_ledger.jsonl"},"merkle_proof":{"hash_alg":"sha256","leaf_prefix":"0x00","node_prefix":"0x01","odd_leaf_rule":"duplicate_last","path":[{"sibling":"c73b4fa26a4696f074fde0146d7b8f603d0ae4df4385ddb369c0489c36575757","side":"right"},{"sibling":"6c22e1baeb06c7a27145ad64576f4bdc1364bcf8c42d499777410d507d318adc","side":"left"},{"sibling":"155939d27e764e8d40176c99890229a4300a1e7a5d38b5f30119f8fc20c2d181","side":"left"},{"sibling":"e59fda41faac797644a3118078cc95cbd167664b1aa8126d4093f23ecf63c633","side":"right"},{"sibling":"791b2c1e4d043658bbfcaec464b0807e22eb8647c3867ff53f836052610d7ea6","side":"right"},{"sibling":"dbdc02c17276708d1b8cff713eb66242173fe7727a86c139ab2f58346efa6ad6","side":"right"},{"sibling":"0b6591633a3212977257746858166dde4a12c0138f81b09c09f3ff243f23f3ca","side":"right"},{"sibling":"66ed9d27919b2830cd6c07ec62488d62635d76aad26e26435c6ebbcd12730198","side":"left"},{"sibling":"831b04b4dcc29bcff4577c406291bc4f644057b650a55f064d46d1cab5185326","side":"right"},{"sibling":"1d74b0fb79eace68949b4d82b0e430b1d9eb122c125f67f5be7d50c074c228e7","side":"left"},{"sibling":"c6eaf7a4fcab2db96e9e9423acb6922c80f64882d0f3f50d09e53a4807d23084","side":"left"},{"sibling":"df12eaabc0a370aff5d0488478f48d2b3f90d025c903643f98ea804b017688ec","side":"right"},{"sibling":"ffc4d51379293bc3e1910c7d612f409dc610fd9acf8241793fb89f82e1bad4ef","side":"left"},{"sibling":"62ac6554017807bd83187f5a3e5f4f72d6c482616429c2780e9fff1f4845fa04","side":"left"},{"sibling":"3a5e69cf0803f4c91f3895ed7c9a95748fef240bec4422e167c05300f79f06c0","side":"left"},{"sibling":"f2817ab288b5324fe49770372c7a10f33f7cd11005f8d4c0a730316f5229dc98","side":"left"},{"sibling":"725fac972e772ca0dc598810ea1abc70df472f72d2d6ab8a0baee2b80e5d2f4c","side":"left"},{"sibling":"98fc57dfef8873b512edc8340f7181df57302bb96777625e072235c62d7c5895","side":"right"}]},"schema":"crovia.axiom_proof.v1","seal":{"first_collector_run_id":"","first_receipt_hash":"","jsonl_path":"/opt/crovia/substrate/axiom_ledger.jsonl","key_id":"430895f101d38164","last_collector_run_id":"","last_receipt_hash":"","leaf_count":134292,"merkle_root":"77fc9c28fae777b81da5b495b3115474df6592dfac590333213d3bdf8b94a9b3","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","run_id":"hourly_json_retrofit_20260515T023701Z","schema":"crovia.seal.v1","seal_family_version":"crovia-seal-family/1","seal_kind":"substrate_batch","sealed_at":"2026-05-15T02:37:25Z","sig_algorithm":"ed25519","signature":"68107a834b00b24f5d4501e5ec727445311f132a486567ecc4c72a4e6dff24c8c21f2de3105293353ba5fdbe370d032819af6aa70f694e2e39b6af6737507009","signer_version":"1.1.0"},"trust_root":{"key_id":"430895f101d38164","public_key_hex":"cf742e26f75669dc673cb5c0786a1ae23ae8ca19c347317192ce40c28a7ff25c","signature_algorithm":"ed25519","url":"/registry/canon/TRUST_ROOT.md"},"verifier":{"spec":"/registry/canon/AXIOM_RECEIPT_v1.md","url":"/v/axm_ed2d6506e189308d1b407783a78f4f29f627ad8289658cc045cf77fc127544cc"}}